Cucurbit[8]uril induced heterodimerization of methylviologen and naphthalene functionalized proteins

  • Chem Commun (Camb). 2011 Jun 28;47(24):6798-800. doi: 10.1039/c1cc11197c.
Dana A Uhlenheuer  1 ,  Jacqui F Young ,  Hoang D Nguyen ,  Marcel Scheepstra ,  Luc Brunsveld
Affiliations
  • 1. Laboratory of Chemical Biology, Department of Biomedical Engineering, Technische Universiteit Eindhoven, Den Dolech 2, 5612 AZ Eindhoven, The Netherlands.
PMID: 21499633 DOI: 10.1039/c1cc11197c
Abstract

Cucurbit[8]uril is a supramolecular inducer of protein heterodimerization for proteins appended with methylviologen and naphthalene host elements. Two sets of fluorescent protein pairs, which visualize the specific protein assembly process, enabled the interplay of the supramolecular elements with the proteins to be established.

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