Cyclanoline chloride

Name: Cyclanoline chloride
Brand: MedChemExpress
SKU: HY-120692
Rating: 4.5 (1 reviews)

Cat. No.: HY-120692 Pureza: 96.27%: Ficha de datos
COA

SDS
Instrucciones de manejo
FAQs
Technical Support

Cyclanoline chloride is an alkaloid. Cyclanoline chloride can be isolated from Fangji. Cyclanoline (chloride) inhibits the phosphorylation of JAK2 and STAT3, and induces Apoptosis. Cyclanoline chloride suppresses tumor growth in subcutaneous bladder cancer xenograft models of nude mice. Cyclanoline chloride reverses cisplatin resistance in bladder cancer cells and enhances the efficacy of Cisplatin (HY-17394). Cyclanoline chloride can be used for research related to bladder cancer.

Para uso exclusivo en investigación. No vendemos a pacientes.

Cyclanoline chloride Estructura química

No. CAS : 17472-50-3

Tamaño	Stock	Cantidad
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
50 mg	Obtener un presupuesto
100 mg	Obtener un presupuesto

or Consulta para venta a granel

* Seleccione Cantidad antes de agregar artículos.

This product is a controlled substance and not for sale in your territory.

Revisión del cliente

Based on 1 publication(s) in Google Scholar

Recomendaciones destacadas

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Ver todos los productos específicos de isoformas JAK:

Ver todas las isoformas

JAK1 JAK2 JAK3 Tyk2 JAK

Ver todos los productos específicos de isoformas STAT:

Ver todas las isoformas

STAT3 STAT5 STAT6 STAT1

Actividad biológica
Pureza y Documentación
Referencias
Revisión del cliente

Descripciòn

IC₅₀ & Target^[1]

JAK2

STAT3

In Vitro

Cyclanoline (50 μM; 24 h) chloride inhibits the JAK2/STAT3 pathway in cisplatin-resistant human bladder cancer T24/DR cells, reducing cell migration and invasion, promoting apoptosis, inducing G₀/G₁ phase cell cycle arrest, and reversing cisplatin resistance, with enhanced effects when combined with cisplatin^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Cyclanoline (chloride) (40 mg/kg; i.p.; every 2 days; 13 administrations) chloride significantly inhibits growth of cisplatin-resistant bladder cancer xenografts in nude mice and downregulates p-STAT3 expression^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Balb/c nude (male, 4-5 weeks old, subcutaneous xenograft model)^[1]
Dosage:	40 mg/kg
Administration:	i.p.; every 2 days; 13 administrations
Result:	Reduced tumor volumes and masses significantly compared to control group, with tumor inhibitory effect superior to cisplatin alone. Downregulated p-STAT3 protein expression in tumor tissue significantly compared to control group.

Peso molecular

377.86

Fòrmula

C₂₀H₂₄ClNO₄

No. CAS

17472-50-3

Appearance

Solid

Color

Off-white to light brown

SMILES

C[N@@+]12CCC3=CC(OC)=C(O)C=C3[C@]1([H])CC4=CC=C(OC)C(O)=C4C2.[Cl-]

Structure Classification

Initial Source

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvente y solubilidad

In Vitro:

DMSO : 100 mg/mL (264.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6465 mL	13.2324 mL	26.4648 mL
5 mM	0.5293 mL	2.6465 mL	5.2930 mL
10 mM	0.2646 mL	1.3232 mL	2.6465 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Pureza y Documentación

Purity: 96.27%

Select Batch:

Ficha de datos (274 KB) SDS (251 KB)

COA (250 KB) RP-HPLC (228 KB) LCMS (257 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Li L, et al. Cyclanoline Reverses Cisplatin Resistance in Bladder Cancer Cells by Inhibiting the JAK2/STAT3 Pathway. Anticancer Agents Med Chem. 2024;24(18):1360-1370.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6465 mL	13.2324 mL	26.4648 mL	66.1621 mL
	5 mM	0.5293 mL	2.6465 mL	5.2930 mL	13.2324 mL
	10 mM	0.2646 mL	1.3232 mL	2.6465 mL	6.6162 mL
	15 mM	0.1764 mL	0.8822 mL	1.7643 mL	4.4108 mL
	20 mM	0.1323 mL	0.6616 mL	1.3232 mL	3.3081 mL
	25 mM	0.1059 mL	0.5293 mL	1.0586 mL	2.6465 mL
	30 mM	0.0882 mL	0.4411 mL	0.8822 mL	2.2054 mL
	40 mM	0.0662 mL	0.3308 mL	0.6616 mL	1.6541 mL
	50 mM	0.0529 mL	0.2646 mL	0.5293 mL	1.3232 mL
	60 mM	0.0441 mL	0.2205 mL	0.4411 mL	1.1027 mL
	80 mM	0.0331 mL	0.1654 mL	0.3308 mL	0.8270 mL
	100 mM	0.0265 mL	0.1323 mL	0.2646 mL	0.6616 mL