2. Neuronal Signaling
  3. α-synuclein
  4. D-685

D-685, a prodrug of D-520, exhibits higher in vivo anti-Parkinsonian efficacy in a reserpinized Parkinson's disease (PD) animal model than the parent D-520. D-685 reduces accumulation of human α-synuclein (α-syn) protein. D-685 exhibits facile brain penetration.

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D-685 Chemical Structure

D-685 Chemical Structure

CAS No. : 2893801-00-6

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Description

D-685, a prodrug of D-520, exhibits higher in vivo anti-Parkinsonian efficacy in a reserpinized Parkinson's disease (PD) animal model than the parent D-520. D-685 reduces accumulation of human α-synuclein (α-syn) protein. D-685 exhibits facile brain penetration[1].

In Vivo

D-685 (12 mg/kg; intraperitoneally daily for 1 month) reduces the accumulation of α-synuclein in α-Syn tg mice[1].
D-685 (10 μmol/kg; ip) is not only highly efficacious in reversing akinesia in male and female Sprague-Dawley rats weighing 220-225 g, compared to Reserpine (HY-N0480; 5.0 mg/kg; SC) alone, but also demonstrates significant enhancement of locomotion for the entire duration of the 6 h study[1].
D-685 exhibits facile penetration into the brain under ip administration with a high brain-to-plasma ratio (B/P: 4)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Five-month-old D-Line α-syn tg Balb/c female mice 20-22 g[1]
Dosage: 12 mg/kg
Administration: Intraperitoneally daily for 1 month
Result: Caused a significant reduction in α-syn accumulation in the neocortex and the striatum and a trend toward a reduction in the CA3 region of the hippocampus.
There was a significant reduction in phospho-α-syn accumulation in all regions examined.
Molecular Weight

513.67

Formula

C32H39N3O3
CAS No.
SMILES

OC1=C2CC[C@H](N(CCN3CCN(C4=CC=C(C5=CC=C(OCO6)C6=C5)C=C4)CC3)CCC)CC2=CC=C1
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Room temperature in continental US; may vary elsewhere.
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References
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D-685 Related Classifications

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  • Do most proteins show cross-species activity?

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Keywords:

D-6852893801-00-6D685D 685α-synucleinα-SynProdrugD-520anti-ParkinsonianParkinson's diseasePDα-synbrain penetrationInhibitorinhibitorinhibit

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