APOL1-IN-1
Based on 1 Customer Validation
APOL1-IN-1 is an apolipoprotein L1 (APOL1) inhibitor that suppresses the functional activity of the APOL1 G1 risk variant. APOL1-IN-1 inhibits the pore function of APOL1, thereby reducing APOL1-mediated membrane permeability and abnormal ion flux, and thus intervenes in APOL1-related cellular injury processes. APOL1-IN-1 is used in research related to focal segmental glomerulosclerosis and non-diabetic kidney disease.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 99.85%
- CAS. Nr.: 2446817-72-5
- Formel: C21H20FN3O3
- Molecular Weight:381.40
-
Speicherung:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
-
Lösungsmittel & Löslichkeit
- Protokoll
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
APOL1 |
In Vitro
APOL1-IN-1 (16 h; followed by 2.5 h AlamarBlue incubation) inhibits recombinant G1 APOL1-mediated lysis of Trypanosoma brucei brucei, with an IC50 <0.25 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS. Nr. 2446817-72-5
-
Appearance Solid
-
Molecular Weight 381.40
-
Formel C21H20FN3O3
-
Color White to off-white
-
SMILES
O=C(N[C@@H]1C(NC[C@H]1O)=O)CCC2=C(C3=CC=C(F)C=C3)NC4=C2C=CC=C4
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 125 mg/mL (327.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Reinheit & Dokumentation
-
Data Sheet (294 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6219 mL | 13.1096 mL | 26.2192 mL | 65.5480 mL |
| 5 mM | 0.5244 mL | 2.6219 mL | 5.2438 mL | 13.1096 mL | |
| 10 mM | 0.2622 mL | 1.3110 mL | 2.6219 mL | 6.5548 mL | |
| 15 mM | 0.1748 mL | 0.8740 mL | 1.7479 mL | 4.3699 mL | |
| 20 mM | 0.1311 mL | 0.6555 mL | 1.3110 mL | 3.2774 mL | |
| 25 mM | 0.1049 mL | 0.5244 mL | 1.0488 mL | 2.6219 mL | |
| 30 mM | 0.0874 mL | 0.4370 mL | 0.8740 mL | 2.1849 mL | |
| 40 mM | 0.0655 mL | 0.3277 mL | 0.6555 mL | 1.6387 mL | |
| 50 mM | 0.0524 mL | 0.2622 mL | 0.5244 mL | 1.3110 mL | |
| 60 mM | 0.0437 mL | 0.2185 mL | 0.4370 mL | 1.0925 mL | |
| 80 mM | 0.0328 mL | 0.1639 mL | 0.3277 mL | 0.8193 mL | |
| 100 mM | 0.0262 mL | 0.1311 mL | 0.2622 mL | 0.6555 mL |
APOL1-IN-1 Related Classifications
HY-141885 Related Classifications
Powered by Bioz