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Art. -Nr.: HY-123345

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CRT 0105446

Name: CRT 0105446
Brand: MedChemExpress
SKU: HY-123345
Price: 91.00 USD
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Rating: 5 (1 reviews)

CRT 0105446 (compound 22d) is a LIMK1 inhibitor, with an IC₅₀ of 8 nM.

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CAS. Nr.: 1661846-05-4
Formel: C₂₀H₁₈F₃N₃O₂S
Molecular Weight:421.44

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

CRT 0105446 Chemical Structure

CAS. Nr.: 1661846-05-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

CRT 0105446 (compound 22d) is a LIMK1 inhibitor, with an IC₅₀ of 8 nM^[1].

Alle LIM Kinase (LIMK) Isoform-spezifische Produkte anzeigen :

LIMK1
LIMK2

Cellular Effect

Cell Line	Type	Value	Description	References
Sf21	IC₅₀	0.008 μM Compound: 22d	Inhibition of recombinant N-terminal 6His-tagged LIMK1 (unknown origin) expressed in Sf21 cells by HTRF assay using cofilin as a substrate Inhibition of recombinant N-terminal 6His-tagged LIMK1 (unknown origin) expressed in Sf21 cells by HTRF assay using cofilin as a substrate	[PMID: 26356364]
ZR-75-1	IC₅₀	2 μM Compound: 22d	Inhibition of LIMK1 in human ZR75-1 cells assessed as inhibition of cofilin phosphorylation after 5 hrs Inhibition of LIMK1 in human ZR75-1 cells assessed as inhibition of cofilin phosphorylation after 5 hrs	[PMID: 26356364]

In Vitro

CRT 0105446 (compound 22d) inhibits the invasion of the cells through matrigel at a concentration of 3 µM, whilst not significantly affecting cell viability even at the higher compound concentration of 10 µM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 1661846-05-4
Molecular Weight 421.44
Formel C₂₀H₁₈F₃N₃O₂S
SMILES

CC(C(NC1=NC=C(S1)C2=C(C=NC=C2)C3=CC=C(C=C3C(F)(F)F)OC)=O)C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Mark D Charles, et al. Discovery, Development, and SAR of Aminothiazoles as LIMK Inhibitors with Cellular Anti-Invasive Properties. J Med Chem. 2015 Oct 22;58(20):8309-13. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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