CITED1 - Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1 Gene

Also Known as MSG1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4435

About CITED1

Cytogenetic location: Xq13.1 Genomic coordinates (GRCh38): X:72,301,646-72,307,157 (from NCBI)

This gene has 11 transcripts (splice variants), 163 orthologues and 2 paralogues. Restricted expression toward testis (RPKM 42.2).

Summary

This gene encodes a member of the CREB-binding protein/p300-interacting transactivator with Asp/Glu-rich C-terminal domain (CITED) family of proteins. The encoded protein, also known as melanocyte-specific gene 1, may function as a transcriptional coactivator and may play a role in pigmentation of melanocytes. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009]

CITED1 Products (4)

mRNA	Protein	Name
NM_001144885.2	NP_001138357.1	cbp/p300-interacting transactivator 1 isoform 2
NM_001144886.2	NP_001138358.1	cbp/p300-interacting transactivator 1 isoform 1
NM_001144887.2	NP_001138359.1	cbp/p300-interacting transactivator 1 isoform 1
NM_004143.4	NP_004134.2	cbp/p300-interacting transactivator 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables LBD domain binding	IDA IDA: Inferred from direct assay	11581164	GOA
enables co-SMAD binding	IPI IPI: Inferred from physical interaction	9707553	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9707553	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	21172805	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	9707553	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in SMAD protein signal transduction	IDA IDA: Inferred from direct assay	9707553	GOA
involved in melanocyte differentiation	IEP IEP: Inferred from expression pattern	8901575	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11581164	GOA
involved in negative regulation of neuron apoptotic process	IDA IDA: Inferred from direct assay	21172805	GOA
involved in nucleocytoplasmic transport	IDA IDA: Inferred from direct assay	16864582	GOA
involved in pigmentation	IEP IEP: Inferred from expression pattern	8901575	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	9434189	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	21172805	GOA
involved in regulation of apoptotic process	IDA IDA: Inferred from direct assay	21172805	GOA
involved in response to estrogen	IDA IDA: Inferred from direct assay	11581164	GOA
involved in response to transforming growth factor beta	IDA IDA: Inferred from direct assay	9707553	GOA
involved in transforming growth factor beta receptor signaling pathway	IDA IDA: Inferred from direct assay	9707553	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	16864582	GOA
located in cytosol	IDA IDA: Inferred from direct assay	16864582	GOA
located in nucleus	IDA IDA: Inferred from direct assay	8901575	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CITED1 Protein Structure

CITED

0
100
193 a.a.

Protein Preferred Names	Protein Names
cbp/p300-interacting transactivator 1	melanocyte-specific gene 1

CITED1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	CITED1	Q99966	ESR1	Homo sapiens	P03372	Anti Tag CoIP	11581164

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Renal Hypoplasia
Thyroid Gland Follicular Carcinoma	Follicular Thyroid Carcinoma Follicular Adenocarcinoma Follicular Adenocarcinoma, Well Differentiated Follicular Carcinoma Thyroid Adenocarcinoma Adenocarcinoma, Follicular
Microphthalmia	Microphthalmos Isolated Anophthalmia-Microphthalmia Syndrome Isolated Microphthalmia-Anophthalmia-Coloboma Simple Microphthalmos Clinical Anophthalmia Isolated Anophthalmia - Microphthalmia Isolated Pure Microphthalmia Mac Spectrum Microphthalmia-Anophthalmia-Coloboma Spectrum Primitive Anophthalmia Globe Of Eye Small Small Eyeball Hypoplasia Of Eye Isolated Nanophthalmos Rudimentary Eye Dysplasia Of Eye
Intellectual Developmental Disorder, X-Linked, Syndromic, Wilson-Turner Type	Wilson-Turner Syndrome WTS Mrxs6 X-Linked Intellectual Disability-Gynecomastia-Obesity Syndrome Mrxswt Wilson-Turner X-Linked Mental Retardation Syndrome Mental Retardation, X-Linked, Syndromic 6 Mental Retardation, X-Linked, With Gynecomastia And Obesity Intellectual Disability, X-Linked, Syndromic 6 Intellectual Disability, X-Linked, With Gynecomastia And Obesity Wilson Turner Intellectual Disability Syndrome X-Linked Intellectual Disability - Gynecomastia - Obesity
Wilms Tumor 1	Nephroblastoma Wilms Tumor WT1 Wilms' Tumor Bilateral Wilms Tumor Wilms Tumor, Type 1 Wilms Tumor, Somatic Adult Nephroblastoma Wt1 Disorder Renal Embryonic Tumor Adult Kidney Wilms Tumor Childhood Kidney Wilms Tumor Nonanaplastic Kidney Wilms Tumor

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-W105310A	Croconic acid disodium		99.98%	Unkown
HY-RS02728	CITED1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CITED1	RGD	RGD:620781
Canis familiaris	CITED1	VGNC	VGNC:39283
Mus musculus	CITED1	MGD	MGI:108023
Felis catus	CITED1	VGNC	VGNC:60910
Bos taurus	CITED1	VGNC	VGNC:27376
Macaca mulatta	CITED1	VGNC	VGNC:71227
Others	CITED1	NCBI