Art. -Nr.: HY-N1964

Gibberellic acid

(Synonyms: Gibberellin A3)

1 Cited Publications

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Gibberellic acid (GA₃) is a natural plant growth regulator with oral bioactivity. Gibberellic acid governs multiple plant developmental events, including seed germination, cell elongation, floral organ formation, and rice spikelet fertility. Gibberellic acid optimizes root morphology and secondary metabolite production in Echinacea purpurea hairy roots, and serves as a bioactive seed priming agent to improve chilling stress tolerance in chickpea. Gibberellic acid mediates modulation of enzyme activity and secondary metabolism in plants and exerts tissue-specific regulatory effects on antioxidant systems and lipid peroxidation in rats. Gibberellic acid can be used in studies of plant growth, metabolism, and abiotic stress responses.

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Reinheit: 99.26%
CAS. Nr.: 77-06-5
Formel: C₁₉H₂₂O₆
Molecular Weight:346.37

Speicherung:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Gibberellic acid Chemical Structure

CAS. Nr.: 77-06-5

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Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
CA46	IC₅₀	>10000 nM Compound: JRA-001	Cytotoxicity against human CA46 cells assessed as reduction in cell viability measured after 24 hrs by CellTiter-Glo luminescent assay Cytotoxicity against human CA46 cells assessed as reduction in cell viability measured after 24 hrs by CellTiter-Glo luminescent assay	[PMID: 33062173]
HCC1599	IC₅₀	>10000 nM Compound: JRA-001	Cytotoxicity against human HCC1599 cells assessed as reduction in cell viability measured after 24 hrs by CellTiter-Glo luminescent assay Cytotoxicity against human HCC1599 cells assessed as reduction in cell viability measured after 24 hrs by CellTiter-Glo luminescent assay	[PMID: 33062173]
HEK-293T	IC₅₀	>10000 nM Compound: JRA-001	Cytotoxicity against human HEK293T cells assessed as reduction in cell viability measured after 24 hrs by CellTiter-Glo luminescent assay Cytotoxicity against human HEK293T cells assessed as reduction in cell viability measured after 24 hrs by CellTiter-Glo luminescent assay	[PMID: 33062173]
Hs-578T	IC₅₀	>10000 nM Compound: JRA-001	Cytotoxicity against human Hs-578T cells assessed as reduction in cell viability measured after 24 hrs by CellTiter-Glo luminescent assay Cytotoxicity against human Hs-578T cells assessed as reduction in cell viability measured after 24 hrs by CellTiter-Glo luminescent assay	[PMID: 33062173]
NCI-H446	IC₅₀	>10000 nM Compound: JRA-001	Cytotoxicity against human NCI-H446 cells assessed as reduction in cell viability measured after 24 hrs by CellTiter-Glo luminescent assay Cytotoxicity against human NCI-H446 cells assessed as reduction in cell viability measured after 24 hrs by CellTiter-Glo luminescent assay	[PMID: 33062173]
PSN1	IC₅₀	>10000 nM Compound: JRA-001	Cytotoxicity against human PSN1 cells assessed as reduction in cell viability measured after 24 hrs by CellTiter-Glo luminescent assay Cytotoxicity against human PSN1 cells assessed as reduction in cell viability measured after 24 hrs by CellTiter-Glo luminescent assay	[PMID: 33062173]
RCK8	IC₅₀	>10000 nM Compound: JRA-001	Cytotoxicity against human RC-K8 cells assessed as reduction in cell viability measured after 24 hrs by CellTiter-Glo luminescent assay Cytotoxicity against human RC-K8 cells assessed as reduction in cell viability measured after 24 hrs by CellTiter-Glo luminescent assay	[PMID: 33062173]
SUD4	IC₅₀	>10000 nM Compound: JRA-001	Cytotoxicity against human SU-DHL-4 cells assessed as reduction in cell viability measured after 24 hrs by CellTiter-Glo luminescent assay Cytotoxicity against human SU-DHL-4 cells assessed as reduction in cell viability measured after 24 hrs by CellTiter-Glo luminescent assay	[PMID: 33062173]

In Vitro

Gibberellic acid (GA₃) (0.005-1.0 μM; 50 days) maximally enhances biomass, cell viability, secondary metabolite production (cichoric acid, caftaric acid, chlorogenic acid, lignin, anthocyanins), PAL activity, and free radical scavenging activity in light-grown Echinacea purpurea hairy root cultures, while 0.005 μM and 1.0 μM reduce these parameters relative to the 0.025 μM group^[2].
Gibberellic acid maintains rice spikelet fertility and anther/pollen development by mediating SLR1 repressor degradation to activate GAMYB and downstream male reproductive genes, while GA deficiency induced by low temperature or GA signaling mutation impairs pollen development and results in male sterility and reduced spikelet fertility in rice^[3].
Gibberellic acid (5-20 μM; continuous low-temperature stress treatment) improves stand establishment, shoot/root growth, relative water content, chlorophyll retention, and flower/branch formation, and reduces electrolyte leakage in both chilling-tolerant Çağatay and chilling-sensitive Akçin chickpea cultivars under low-temperature stress^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:

Echinacea purpurea hairy root cells
Concentration:

0.005 μM, 0.025 μM, 1.0 μM
Incubation Time:

0-50 days continuous incubation
Result:

Moderate 0.025 μM gibberellic acid significantly enhanced hairy root cell viability; low (0.005 μM) and high (1.0 μM) concentrations exhibited inhibitory effects on cell viability versus control group.

In Vivo

Gibberellic acid (75 ppm; p.o.; ad libitum; 25 days) increases lipid peroxidation in spleen and lung tissues, and alters antioxidant enzyme activities in spleen, kidney, lung, and heart tissues in male Sprague-Dawley rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague-Dawley albino (male, 4 months old, 250-300 g average weight)^[1]
Dosage:

75 ppm (equivalent to ~2 mg/day per rat)
Administration:

p.o.; 25 days
Result:

Significantly increased malondialdehyde (MDA) content in spleen and lung tissues compared to controls.
Significantly increased superoxide dismutase (SOD) activity in spleen and kidney tissues compared to controls.
Significantly decreased glutathione reductase (GR) activity in spleen tissue and significantly increased in kidney tissue compared to controls.
Significantly increased glutathione-S-transferase (GST) activity in spleen and lung tissues, and significantly decreased in heart tissue compared to controls.

Chemical Information

CAS. Nr. 77-06-5
Appearance Solid
Molecular Weight 346.37
Formel C₁₉H₂₂O₆
Color White to off-white
SMILES

OC([C@H]1[C@@]([C@]23C)([H])[C@@](OC2=O)(C=C[C@@H]3O)[C@@](CC4)([H])[C@]1(C5)C[C@]4(O)C5=C)=O
Synonyms

Gibberellin A3
Initial Source
- Microorganisms
Gibberella fujikuroi
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (1)

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Journal Impact Factor

Cell Res

Engineered poly(A)-surrogates for translational regulation and therapeutic biocomputation in mammalian cells. [Abstract]

2024 Jan;34(1):31-46. PMID: 38172533

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (288.71 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 4 mg/mL (11.55 mM; ultrasonic and warming and heat to 60°C)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.8871 mL

14.4354 mL

28.8709 mL

5 mM

0.5774 mL

2.8871 mL

5.7742 mL

10 mM

0.2887 mL

1.4435 mL

2.8871 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.08 mg/mL (6.01 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.08 mg/mL (6.01 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.08 mg/mL (6.01 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (283 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Kwon CT, et al. Gibberellic Acid: A Key Phytohormone for Spikelet Fertility in Rice Grain Production. Int J Mol Sci. 2016 May 23;17(5). [Content Brief]

[2]. Aziz T, et al. Seed priming with gibberellic acid rescues chickpea (Cicer arietinum L.) from chilling stress[J]. Acta Physiologiae Plantarum, 2020, 42: 1-10.

[3]. Celik I, et al. Abcisic acid and gibberellic acid cause increased lipid peroxidation and fluctuated antioxidant defense systems of various tissues in rats. J Hazard Mater. 2007 Sep 30;148(3):623-9. [Content Brief]

[4]. Abbasi BH, et al. Gibberellic acid increases secondary metabolite production in Echinacea purpurea hairy roots. Appl Biochem Biotechnol. 2012 Dec;168(7):2057-66. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O / DMSO	1 mM	2.8871 mL	14.4354 mL	28.8709 mL	72.1772 mL
	5 mM	0.5774 mL	2.8871 mL	5.7742 mL	14.4354 mL
	10 mM	0.2887 mL	1.4435 mL	2.8871 mL	7.2177 mL
DMSO	15 mM	0.1925 mL	0.9624 mL	1.9247 mL	4.8118 mL
	20 mM	0.1444 mL	0.7218 mL	1.4435 mL	3.6089 mL
	25 mM	0.1155 mL	0.5774 mL	1.1548 mL	2.8871 mL
	30 mM	0.0962 mL	0.4812 mL	0.9624 mL	2.4059 mL
	40 mM	0.0722 mL	0.3609 mL	0.7218 mL	1.8044 mL
	50 mM	0.0577 mL	0.2887 mL	0.5774 mL	1.4435 mL
	60 mM	0.0481 mL	0.2406 mL	0.4812 mL	1.2030 mL
	80 mM	0.0361 mL	0.1804 mL	0.3609 mL	0.9022 mL
	100 mM	0.0289 mL	0.1444 mL	0.2887 mL	0.7218 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

Gibberellic acid

1 Cited Publications

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Gibberellic acid

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Publications Citing Use of MedChemExpress (MCE) Gibberellic acid

Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Gibberellic acid Related Classifications

HY-N1964 Related Classifications