MS7829
MS7829 is a deubiquitinase-targeting chimera (DUBTAC) that targets cGAS. MS7829 recruits OTUB1 to cGAS, binds covalently to OTUB1, stabilizes the protein abundance of cGAS, and activates the cGAS-STING-IRF3 innate immune signaling pathway in an OTUB1-dependent manner. MS7829 is applicable to cancer-related research.
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- CAS. Nr.: 3060519-67-4
- Formel: C44H57Cl2N9O6S
- Molecular Weight:910.95
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
MS7829 (0-10 μM; 0-24 h) stabilizes cGAS and elevates downstream STING protein levels in HeLa cells in vitro in a concentration- and time-dependent manner, without affecting cGAS transcription[1].
MS7829 (5-10 μM; 24 h)-mediated cGAS stabilization and STING elevation in HeLa cells is dependent on specific binding to both cGAS and OTUB1[1].
MS7829 (5 μM; 24 h) activates the cGAS/STING/IRF3 signaling pathway in HeLa cells in an OTUB1-dependent manner, increasing cGAMP production and downstream cytokine gene expression[1].
MS7829 (5 μM; days-2 weeks) potently suppresses HeLa cell proliferation and clonogenicity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa cells
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Concentration:5 μM
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Incubation Time:2 days (proliferation assay); 2 weeks (clonogenicity assay)
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Result:Significantly suppressed cell proliferation compared to vehicle control at 5 μM for 2 days.
Drastically reduced cell colony formation at 5 μM for 2 weeks.
Chemical Information
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CAS. Nr. 3060519-67-4
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Molecular Weight 910.95
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Formel C44H57Cl2N9O6S
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SMILES
ClC1=C(NC2=C3CN(C(CO)=O)CC2)C3=C(C4=NN(CC(NCCCCCCCCCNC(CCC5=CC=C(N6C(CN(C(/C=C/CN(C)C)=O)CC6)=O)S5)=O)=O)C=C4)C=C1Cl
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
MS7829 Related Classifications
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