CD98/SLC3A2
CD98, the product of SLC3A2, is the shared heavy chain of the heterodimeric amino acid transporter family. Through a disulfide bond it pairs with light chains such as LAT1 (SLC7A5), forming transporters for large neutral amino acids that fuel lymphocyte activation and tumor anabolism. Independent of transport, the CD98 ectodomain engages beta-1 integrins, potentiating cell spreading, migration and survival signals. Expression rises sharply upon T-cell activation and in proliferating epithelia and carcinomas, which keeps CD98 in focus as a marker of activation and a proposed antibody-therapy target in hematologic malignancies. Recombinant CD98 is used to study transporter assembly and integrin co-signaling.
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CD98/SLC3A2 Recombinant Proteins (7)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
