Azaphilone-9
Azaphilone-9 (AZA-9) is an inhibitor of HuR-ARE RNA interaction (IC50=1.2 μM) by binding RNA-binding protein Hu antigen R (HuR). The HuR-RNA interactions stabilize many oncogenic mRNAs in tumors. Thus Azaphilone-9 potentially inhibit cancer cell growth and progression.
For research use only. We do not sell to patients.
- CAS No.: 1448460-87-4
- Formula: C21H23BrO5
- Molecular Weight:435.31
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
HuR-ARE[1]
Azaphilone-9 is a HuR-RNA inhibitor. However HuR binds and stabilizes the AREs of the oncogene Musashi1 (Msi1) and anti-apoptotic proteins, Bcl2 and XIAP, thereby up-regulating their expression and activating the Wnt/Notch signaling pathway and inhibiting apoptosis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1448460-87-4
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Molecular Weight 435.31
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Formula C21H23BrO5
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SMILES
O=C1C(C)(OC(C)=O)C(C2=COC(/C=C/C(C)=C/[C@@H](C)CC)=CC2=C1Br)=O
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Synonyms
AZA-9
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Azaphilone-9 Related Classifications
HY-124844 Related Classifications
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