TNFSF11 - TNF superfamily member 11 Gene

Also Known as ODF; OPGL; RANKL; TRANCE

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 117516

About TNFSF11

Primary_assembly 15: 53,673,877-53,705,445 reverse strand.mRatBN7.2:CM026988.1

This gene has 1 transcript (splice variant), 215 orthologues, 8 paralogues and is associated with 13 phenotypes. Biased expression in Thymus (RPKM 39.9), Spleen (RPKM 12.2) and 1 other tissue.

Summary

Predicted to enable cytokine activity; identical protein binding activity; and tumor necrosis factor receptor superfamily binding activity. Involved in several processes, including positive regulation of bone resorption; positive regulation of osteoclast differentiation; and response to immobilization stress. Predicted to be located in extracellular space and plasma membrane. Predicted to be integral component of membrane. Biomarker of mucopolysaccharidosis VI and myocarditis. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 2 and osteoporosis. Orthologous to human TNFSF11 (TNF Superfamily member 11). [provided by Alliance of Genome Resources, Apr 2022]

TNFSF11 Products (1)

mRNA Protein Name
NM_057149.2 NP_476490.2 tumor necrosis factor ligand superfamily member 11
Protein Preferred Names Protein Names

tumor necrosis factor ligand superfamily member 11

  • TNF-related activation-induced cytokine

  • osteoclast differentiation factor

  • osteoprotegerin ligand

  • receptor activator of nuclear factor kappa-B ligand

  • tumor necrosis factor (ligand) superfamily, member 11

  • tumor necrosis factor superfamily member 11

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P9958A Denosumab (anti-TNFSF11) Inhibitor 99.9% Phase 4

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14819 TNFSF11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14820 Tnfsf11 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14821 TNFSF11 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991362 GB-223 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens TNFSF11 NCBI NCBI:8600