Ido1 - indoleamine 2,3-dioxygenase 1 Gene

Also Known as Ido; Indo

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15930

About Ido1

Chromosome 8: 25,074,152-25,087,025 reverse strand.GRCm39:CM001001.3

This gene has 2 transcripts (splice variants), 98 orthologues and is associated with 34 phenotypes. Biased expression in genital fat pad adult (RPKM 37.1), mammary gland adult (RPKM 7.7) and 2 other tissues.

Summary

Enables tryptophan 2,3-dioxygenase activity. Acts upstream of or within several processes, including carboxylic acid metabolic process; regulation of apoptotic process; and regulation of cytokine production. Located in smooth muscle contractile fiber and stereocilium bundle. Is expressed in cerebral cortex; corpus striatum; embryo; extraembryonic component; and hippocampus. Used to study pre-eclampsia. Orthologous to human IDO1 (indoleamine 2,3-dioxygenase 1). [provided by Alliance of Genome Resources, Apr 2022]

Ido1 Products (2)

mRNA Protein Name
NM_008324.3 NP_032350.1 indoleamine 2,3-dioxygenase 1 isoform 1
NM_001293690.2 NP_001280619.1 indoleamine 2,3-dioxygenase 1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21804557 MGI
enables tryptophan 2,3-dioxygenase activity IDA
IDA: Inferred from direct assay
11751753 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of T cell proliferation IMP
IMP: Inferred from mutant phenotype
18077788 MGI
acts upstream of or within cytokine production involved in inflammatory response IMP
IMP: Inferred from mutant phenotype
19234212 MGI
acts upstream of or within inflammatory response IMP
IMP: Inferred from mutant phenotype
18480171 MGI
acts upstream of interleukin-10 production IMP
IMP: Inferred from mutant phenotype
19234212 MGI
acts upstream of interleukin-12 production IMP
IMP: Inferred from mutant phenotype
19234212 MGI
acts upstream of or within kynurenic acid biosynthetic process IMP
IMP: Inferred from mutant phenotype
19234212 MGI
acts upstream of or within multicellular organismal response to stress IMP
IMP: Inferred from mutant phenotype
19234218 MGI
acts upstream of or within negative regulation of T cell apoptotic process IMP
IMP: Inferred from mutant phenotype
18077788 MGI
acts upstream of or within negative regulation of T cell proliferation IMP
IMP: Inferred from mutant phenotype
18077788 MGI
acts upstream of or within negative regulation of activated T cell proliferation IMP
IMP: Inferred from mutant phenotype
18077788 MGI
acts upstream of or within negative regulation of interleukin-10 production IMP
IMP: Inferred from mutant phenotype
19234212 MGI
acts upstream of or within positive regulation of T cell tolerance induction IMP
IMP: Inferred from mutant phenotype
9712583 MGI
acts upstream of or within positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
18480171 MGI
acts upstream of or within positive regulation of chronic inflammatory response IMP
IMP: Inferred from mutant phenotype
18436652 MGI
acts upstream of or within positive regulation of interleukin-12 production IMP
IMP: Inferred from mutant phenotype
19234212 MGI
acts upstream of or within positive regulation of type 2 immune response IMP
IMP: Inferred from mutant phenotype
18436652 MGI
involved in quinolinate biosynthetic process IDA
IDA: Inferred from direct assay
2419335 MGI
acts upstream of or within response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
19234212 MGI
acts upstream of or within swimming behavior IMP
IMP: Inferred from mutant phenotype
19234218 MGI
acts upstream of or within tryptophan catabolic process to kynurenine IDA
IDA: Inferred from direct assay
2419335 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
17671174 MGI
located in smooth muscle contractile fiber IDA
IDA: Inferred from direct assay
19741271 MGI
located in stereocilium bundle IDA
IDA: Inferred from direct assay
19741271 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ido1 Protein Structure

IDO

IDO: pfam01231 (15 - 401)

  • 0
  • 100
  • 200
  • 300
  • 407 a.a.
Protein Preferred Names Protein Names

indoleamine 2,3-dioxygenase 1

  • IDO-1

  • indole 2,3-dioxygenase

  • indoleamine-pyrrole 2,3 dioxygenase

Ido1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Ido1 P28776 Ptpn11 Mus musculus P35235
Pull Down
21804557
Intra
Ido1 P28776 Ptpn11 Mus musculus P35235
Anti Bait CoIP
21804557
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Ido1 Proteins

Cat. No. Product Name Accession Purity
HY-P72616 IDO-1 Protein, Mouse (His) P28776 (M1-P407) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N0110 Palmatine chloride Inhibitor 99.87% Unkown
HY-N0110A Palmatine Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Phase
HY-15689 Epacadostat Inhibitor 99.72% Phase 3
HY-101560 Linrodostat Inhibitor 99.81% Phase 3
HY-139204 BMS-986242 Inhibitor 98.85% Phase 2
HY-101111 PF-06840003 Inhibitor 99.87% Phase 1
HY-13983 IDO-IN-7 Inhibitor 99.80% Phase 1
HY-111540 LY-3381916 Inhibitor 99.92% Phase 1

Pre-clinical Phase

Bioactive Molecules (59)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-151108 IDO1/TDO-IN-4 Inhibitor 99.74% Unkown
HY-131911 PROTAC IDO1 Degrader-1 Inhibitor 99.00% Unkown
HY-N0110B Palmatine hydroxide Inhibitor 99.64% Unkown
HY-148383 DP00477 Inhibitor 98.21% Unkown
HY-W113615 4-Phenyl-1H-1,2,3-triazole Inhibitor 99.35% Unkown
HY-145280 IDO1/2-IN-1 Inhibitor 98.06% Unkown
HY-151886 NU223612 Inhibitor 99.41% Unkown
HY-144652 IDO1-IN-19 Inhibitor 98.82% Unkown
HY-78699 2-Hydrazinobenzothiazole Inhibitor 99.95% Unkown
HY-151093 IDO2-IN-1 Inhibitor 98.10% Unkown
HY-178011 IDO1-IN-28 Inhibitor 99.89% Unkown
HY-18769 BMS-978587 Inhibitor 99.92% Unkown
HY-112867 Amg-1 Inhibitor / Unkown
HY-16987 IDO-IN-3 Inhibitor 98.44% Unkown
HY-139205 BMT-297376 Inhibitor 99.14% Unkown
HY-173066 NU227326 Degrader / Unkown
HY-112147 IDO1 and HDAC1 Inhibitor Inhibitor / Unkown
HY-177785 iDeg-6 Degrader / Unkown
HY-178954 IDO1-IN-32 Inhibitor / Unkown
HY-184993 IDO1 ligand-2 Ligand / Unkown
HY-178024 IDO1-IN-29 Inhibitor / Unkown
HY-184077 IDO1-IN-35 Inhibitor / Unkown
HY-177784 iDeg-3 Degrader / Unkown
HY-184129 IDO1/TDO-IN-15 Inhibitor / Unkown
HY-W1060365 4-((Aminooxy)methyl)phenol Inhibitor / Unkown
HY-144465 IDO1-IN-15 Inhibitor / Unkown
HY-149227 IDO1-IN-21 Inhibitor / Unkown
HY-154387 1-Isopropyltryptophan Inhibitor / Unkown
HY-184134 IDO1/TDO-IN-16 Inhibitor / Unkown
HY-184040 TDO-IN-3 Inhibitor / Unkown
HY-173513 IDO1/TDO-IN-8 Inhibitor / Unkown
HY-144778 IDO1/TDO-IN-1 Inhibitor / Unkown
HY-184104 IDO1/TDO-IN-17 Inhibitor / Unkown
HY-148336A IDO1/TDO-IN-5 Inhibitor / Unkown
HY-144466 IDO1-IN-16 Inhibitor / Unkown
HY-184078 8-F-2-(Me-Pip-Me)-Tryptanthrin Inhibitor / Unkown
HY-158334 NDs-IN-1 Inhibitor / Unkown
HY-181947 IDO1-IN-33 Inhibitor / Unkown
HY-147772 ZC0101 Inhibitor / Unkown
HY-184105 IDO1-IN-36 Inhibitor / Unkown
HY-183317 IDO1-IN-34 Inhibitor / Unkown
HY-144468 IDO1-IN-17 Inhibitor / Unkown
HY-144273 IDO1-IN-13 Inhibitor / Unkown
HY-181941 IDO1/TDO-IN-11 Inhibitor / Unkown
HY-173067 IDO1 ligand-1 / Unkown
HY-184028 IDO1-IN-37 Inhibitor / Unkown
HY-175182 IDO1-IN-27 Inhibitor / Unkown
HY-184135 IDO/TDO-IN-2 Inhibitor / Unkown
HY-148572 NAMPT/IDO1-IN-1 Inhibitor / Unkown
HY-184027 IDO1/TDO-IN-12 Inhibitor / Unkown
HY-184129A (E)-IDO1/TDO-IN-15 Inhibitor / Unkown
HY-130607 IDO1-IN-2 Inhibitor / Unkown
HY-120742 MMG-0358 Inhibitor / Unkown
HY-144274 IDO1-IN-14 Inhibitor / Unkown
HY-D0033 Roxyl-9 Inhibitor 99.22% Unkown
HY-178693 IDO1-IN-31 Inhibitor / Unkown
HY-101560A Linrodostat mesylate Inhibitor / Unkown
HY-134920 LW106 Inhibitor / Unkown
HY-138576 IDO1-IN-26 Inhibitor 98.22% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ido1 NCBI NCBI:3620