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Cat. No.: HY-178693

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IDO1-IN-31

IDO1-IN-31 (Compound 17g) is an IDO1 agonist with an IC₅₀ of 77 nM. IDO1-IN-31 can be used for the study of neurological diseases and cancers.

For research use only. We do not sell to patients.

CAS No.: 1622922-42-2
Formula: C₂₀H₁₄BrN₅OS
Molecular Weight:452.33

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

IDO1-IN-31 Chemical Structure

CAS No.: 1622922-42-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IDO1-IN-31 (Compound 17g) is an IDO1 agonist with an IC₅₀ of 77 nM. IDO1-IN-31 can be used for the study of neurological diseases and cancers^[1].

IC₅₀ & Target

^[1]

IDO1

77 nM (IC₅₀)

All Indoleamine 2,3-Dioxygenase (IDO) Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	IC₅₀ relative	35000 nM Compound: EOS101885	Cytotoxicity activity against human HepG2 cells assessed by CellTiter-Glo luminescent cell viability assay. Cytotoxicity activity against human HepG2 cells assessed by CellTiter-Glo luminescent cell viability assay.	10.6019/EOS300108

Chemical Information

CAS No. 1622922-42-2
Molecular Weight 452.33
Formula C₂₀H₁₄BrN₅OS
SMILES

N#CC1=CC=C(NC(NCC2=CN=C3SC=C(N32)C4=CC=C(Br)C=C4)=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Tojo S, et al. Crystal Structures and Structure-Activity Relationships of Imidazothiazole Derivatives as IDO1 Inhibitors. ACS Med Chem Lett. 2014 Aug 21;5(10):1119-23. [Content Brief]

Calculators

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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