ARMC8 - armadillo repeat containing 8 Gene

Also Known as GID5; VID28; S863-2; HSPC056

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 25852

About ARMC8

Cytogenetic location: 3q22.3 Genomic coordinates (GRCh38): 3:138,187,248-138,298,389 (from NCBI)

This gene has 23 transcripts (splice variants) and 211 orthologues. Ubiquitous expression in bone marrow (RPKM 8.0), thyroid (RPKM 5.8) and 25 other tissues.

Summary

Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Located in cytosol and nucleoplasm. Part of ubiquitin Ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

ARMC8 Products (8)

mRNA Protein Name
NM_001267041.2 NP_001253970.1 armadillo repeat-containing protein 8 isoform 3
NM_001267042.3 NP_001253971.1 armadillo repeat-containing protein 8 isoform 4
NM_001282342.2 NP_001269271.1 armadillo repeat-containing protein 8 isoform 5
NM_001363941.2 NP_001350870.1 armadillo repeat-containing protein 8 isoform 6
NM_001363942.1 NP_001350871.1 armadillo repeat-containing protein 8 isoform 7
NM_014154.4 NP_054873.2 armadillo repeat-containing protein 8 isoform 1
NM_015396.6 NP_056211.2 armadillo repeat-containing protein 8 isoform 2
NM_213654.3 NP_998819.1 armadillo repeat-containing protein 8 isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17467196 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
17467196 GOA
located in nucleus IDA
IDA: Inferred from direct assay
17467196 GOA
part of ubiquitin ligase complex IDA
IDA: Inferred from direct assay
29911972 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARMC8 Protein Structure

Arm

Arm: Armadillo/beta-catenin-like repeat (50 - 91)

  • 0
  • 200
  • 400
  • 600
  • 673 a.a.
Protein Preferred Names Protein Names

armadillo repeat-containing protein 8

  • GID complex subunit 5, VID28 homolog

ARMC8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ARMC8 Q8IUR7 TCF12 Homo sapiens Q99081
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Marinesco-Sjogren Syndrome

  • Marinesco-Sjögren Syndrome

  • MSS

  • Marinesco-Garland Syndrome

  • Garland-Moorhouse Syndrome

  • Hereditary Oligophrenic Cerebello-Lental Degeneration

  • Oligophrenic Cerebellolenticular Degeneration

  • Marinesco-Sjogren Syndrome-Hypergonadotrophic Hypogonadism

  • Marinesco-Sjogren Syndrome-Myopathy

  • Marinesco-Sjogren-Garland Syndrome

  • Marinesco-Sjoegren Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01005 ARMC8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus ARMC8 VGNC VGNC:59937
Bos taurus ARMC8 VGNC VGNC:26162
Canis familiaris ARMC8 VGNC VGNC:38128
Rattus norvegicus ARMC8 RGD RGD:1310477
Mus musculus ARMC8 MGD MGI:1921375
Macaca mulatta ARMC8 VGNC VGNC:69898
Others ARMC8 NCBI