HMGN2 - high mobility group nucleosomal binding domain 2 Gene

Also Known as HMG17

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3151

About HMGN2

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:26,472,440-26,476,642 (from NCBI)

This gene has 10 transcripts (splice variants), 126 orthologues and 3 paralogues. Ubiquitous expression in bone marrow (RPKM 279.3), lymph node (RPKM 141.8) and 25 other tissues.

Summary

The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMGN1, the encoded protein may help maintain an open chromatin configuration around transcribable genes. The protein has also been found to have antimicrobial activity against bacteria, viruses and fungi. [provided by RefSeq, Oct 2014]

HMGN2 Products (1)

mRNA Protein Name
NM_005517.4 NP_005508.1 non-histone chromosomal protein HMG-17

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21044950 GOA
Biological Process GO Annotation Evidence References Source
involved in antimicrobial humoral immune response mediated by antimicrobial peptide IMP
IMP: Inferred from mutant phenotype
16204630 GOA
involved in killing of cells of another organism IMP
IMP: Inferred from mutant phenotype
16204630 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
16204630 GOA
located in extracellular space IDA
IDA: Inferred from direct assay
16204630 GOA
located in nucleus IDA
IDA: Inferred from direct assay
16204630 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HMGN2 Protein Structure

HMG14_17

HMG14_17: HMG14 and HMG17 (2 - 89)

  • 0
  • 90 a.a.
Protein Preferred Names Protein Names

non-histone chromosomal protein HMG-17

  • high mobility group nucleosome-binding domain-containing protein 2

HMGN2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HMGN2 P05204 PARP2 Homo sapiens Q9UGN5
Anti Tag CoIP
33961781
Intra
HMGN2 P05204 TERF2 Homo sapiens Q15554
Pull Down
21044950
Intra
HMGN2 P05204 TERF2 Homo sapiens Q15554
BiFC
21044950
Cross: Cross-species interaction Intra: Intraspecies interaction

HMGN2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83094 HMGN2 Antibody (YA2839) WB, IHC-P Human

Related Diseases

Diseases Alias
Microcephaly

  • Microencephaly

  • Microcephalus

  • Microcephalic

  • Nanocephaly

  • Congenital Microcephaly

  • Brain Hypoplasia

  • Brain Nondevelopment

  • Cephalic Hypoplasia

  • Undeveloped Cerebrum

  • Undeveloped Brain

  • Micrencephalon

  • Micrencephaly
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06244 HMGN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20955 Hmgn2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27472 Hmgn2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus HMGN2 MGD MGI:96136
Bos taurus HMGN2 VGNC VGNC:50536
Rattus norvegicus HMGN2 RGD RGD:620649
Others HMGN2 NCBI