PRSS3 - serine protease 3 Gene

Also Known as T9; MTG; TRY3; TRY4; PRSS4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5646

About PRSS3

Cytogenetic location: 9p13.3 Genomic coordinates (GRCh38): 9:33,750,679-33,799,231 (from NCBI)

This gene has 7 transcripts (splice variants), 474 orthologues and 3 paralogues. Restricted expression toward pancreas (RPKM 3091.3).

Summary

This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is expressed in the brain and pancreas and is resistant to common trypsin inhibitors. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene is localized to the locus of T cell receptor beta variable orphans on chromosome 9. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2010]

PRSS3 Products (4)

mRNA Protein Name
NM_001197097.3 NP_001184026.3 trypsin-3 isoform 3 preproprotein
NM_001197098.1 NP_001184027.1 trypsin-3 isoform 4 preproprotein
NM_002771.4 NP_002762.3 trypsin-3 isoform 2 preproprotein
NM_007343.4 NP_031369.3 trypsin-3 isoform 1 preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium ion binding IDA
IDA: Inferred from direct assay
6698368 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
6698368 GOA
enables serine-type endopeptidase activity IDA
IDA: Inferred from direct assay
6698368 GOA
enables serine-type peptidase activity IDA
IDA: Inferred from direct assay
9099703 GOA
Biological Process GO Annotation Evidence References Source
involved in endothelial cell migration IMP
IMP: Inferred from mutant phenotype
15313892 GOA
involved in proteolysis IDA
IDA: Inferred from direct assay
6698368 GOA
involved in zymogen activation IDA
IDA: Inferred from direct assay
6698368 GOA
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
6698368 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRSS3 Protein Structure

Trypsin

Trypsin: Trypsin (81 - 296)

  • 0
  • 100
  • 200
  • 304 a.a.
Protein Preferred Names Protein Names

trypsin-3

  • brain trypsinogen

Recombinant PRSS3 Proteins

Cat. No. Product Name Accession Purity
HY-P71456 PRSS3/Trypsin-3 Protein, Human (His) P35030-1 (I81-N303) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P75985 PRSS3/Trypsin-3 Protein, Human (HEK293, His) P35030-3 (V16-S247) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Thyroiditis

  • Inflammation Of Thyroid

  • Thyroiditis Nos
Hashimoto Thyroiditis

  • Autoimmune Thyroiditis

  • Hashimoto Struma

  • Hashimoto'S Thyroiditis

  • Chronic Lymphocytic Thyroiditis

  • Lymphocytic Thyroiditis

  • Hashimoto Disease

  • Ht

  • Hashimoto'S Disease

  • Hashimoto'S Syndrome

  • Hypothyroidism, Autoimmune

  • Autoimmune Chronic Lymphocytic Thyroiditis

  • Chronic Lymphocytic Thyroiditides

  • Hashimoto Syndrome

  • Hashimotos Thyroiditis

  • Hashimoto Thyroiditis, Susceptibility To

  • Thyroiditis, Autoimmune

  • Lymphomatous Thyroiditis

  • Lymphoid Thyroiditis

  • Chronic Lymphadenoid Thyroiditis

  • Autoimmune Lymphocytic Chronic Thyroiditis

  • Goitre Lymphomatosa

  • Hashitoxicosis

  • Hashimoto Hypothyroidism

  • Lymphadenoid Goitre

  • Struma Lymphomatosa

  • Hyperthyroidism With Hashimoto Disease

  • Hashimoto Thyrotoxicosis

  • Thyrotoxicosis Due To Hashimoto Thyroiditis

  • Struma Lymphomatosis

  • Lymphadenoid Struma
Pancreatitis

  • Mumps Pancreatitis
Pancreatitis, Hereditary

  • Hereditary Pancreatitis

  • Chronic Pancreatitis

  • Hereditary Chronic Pancreatitis

  • Hp

  • Pancreatitis, Chronic, Susceptibility To

  • PCTT

  • Hpc

  • Pancreatitis, Chronic

  • Pancreatitis, Chronic, Protection Against

  • Autosomal Dominant Hereditary Pancreatitis

  • Familial Pancreatitis

  • Cp

  • Pancreatitis Hereditary
Autoimmune Disease Of Endocrine System
Celiac Disease 1

  • Celiac Disease

  • Coeliac Disease

  • Celiac Sprue

  • Celiac Disease, Susceptibility To

  • Gluten-Sensitive Enteropathy

  • Nontropical Sprue

  • Sprue

  • CELIAC1

  • Celiac Disease, Susceptibility To, 1

  • Celiac Sprue 1

  • Celiac Sprue, Susceptibility To, 1

  • Gluten-Sensitive Enteropathy 1

  • Gluten-Sensitive Enteropathy, Susceptibility To, 1

  • Idiopathic Steatorrhea

  • Cœliac Disease

  • Gluten Intolerance

  • Gluten-Induced Enteropathy

  • Gluten Enteropathy

  • Celiac Disease, Susceptibility To, Type 1

  • Childhood Celiac Disease

  • Coeliac Rickets

  • Gee Disease

  • Gee-Herter Disease

  • Heubner-Herter Disease

  • Idiopathic Steatorrhoea

  • Thaysen'S Disease

  • Herter Gee Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11253 PRSS3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17920 Prss3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PRSS3 RGD RGD:1311446
Others PRSS3 NCBI