Ibrilparant
Ibrilparant is a LPA1 receptor antagonist with an IC50 of 0.00753 μM. Ibrilparant exhibits LPA1 calcium flux antagonistic activity, with an IC50 of 3.02 nM. Ibrilparant can be used in research related to various diseases such as cancer and inflammatory diseases.
For research use only. We do not sell to patients.
- CAS No.: 2978107-47-8
- Formula: C25H31NO5
- Molecular Weight:425.52
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
LPA1 Receptor |
In Vitro
Ibrilparant (compound 355) exerts potent functional antagonistic activity against LPA1 in CHO-K1 cells overexpressing human LPA1 and G15a, with an IC50 of 0.00753 μM[1].
Ibrilparant exhibits potent LPA1 calcium flux antagonistic activity in CHO-K1 cells overexpressing human LPA1 and G15a, with an IC50 of 3.02 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 2978107-47-8
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Molecular Weight 425.52
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Formula C25H31NO5
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SMILES
O=C(C1(CCOCC1)NC2=CC=C(C(COC3CC3)=C2)C4=C(C)C(OCC)=CC=C4)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
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Ca2+ Staining Technique
Ca2+ staining is an experimental technique that utilizes specific fluorescent probes (such as Fluo-4 AM, Fura-2, etc.) to qualitatively or quantitatively detect dynamic changes in intracellular Ca2+ concentrations; this is achieved by monitoring the changes in fluorescent signals generated when these probes bind to free intracellular calcium ions. The underlying principle relies primarily on the presence of chelating groups within the probe's molecular structure that possess high affinity for calcium ions.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ibrilparant Related Classifications
HY-184076 Related Classifications
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