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Cat. No.: HY-N9861

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Kayaflavone

Kayaflavone is an amentoflavone type biflavonoid. Kayaflavone has an inhibitory activity against amyloid-β42 cytotoxicity in PC-12 cells with an EC₅₀ value of 5.29 μΜ. Kayaflavone is promising for research of Alzheimer’s disease.

For research use only. We do not sell to patients.

CAS No.: 481-45-8
Formula: C₃₃H₂₄O₁₀
Molecular Weight:580.54

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Kayaflavone Chemical Structure

CAS No.: 481-45-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
PC-12	EC₅₀	5.29 μM Compound: 15	Neuroprotective activity against 0.1 uM amyloid beta 42-induced toxicity in rat PC12 cells assessed as cell viability after 24 hrs by MTT assay Neuroprotective activity against 0.1 uM amyloid beta 42-induced toxicity in rat PC12 cells assessed as cell viability after 24 hrs by MTT assay	[PMID: 26004578]

Chemical Information

CAS No. 481-45-8
Molecular Weight 580.54
Formula C₃₃H₂₄O₁₀
SMILES

O=C1C=C(C2=CC(C3=C(C=C(C4=C3OC(C5=CC=C(OC)C=C5)=CC4=O)O)OC)=C(OC)C=C2)OC6=C1C(O)=CC(O)=C6
Structure Classification
- Flavonoids
- Flavones
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Sasaki H, et al. Inhibitory activities of biflavonoids against amyloid-β peptide 42 cytotoxicity in PC-12 cells. Bioorg Med Chem Lett. 2015 Jul 15;25(14):2831-3. [Content Brief]

[2]. Sun CM, et al. Selective cytotoxicity of ginkgetin from Selaginella moellendorffii. J Nat Prod. 1997 Apr;60(4):382-4. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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