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Cat. No.: HY-183468

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MV152

MV152 serves as the inactive control for the proteasome activity probe MV151. It contains a reduced ethyl sulfone group that replaces the vinyl sulfone reactive group of MV151, while retaining the identical fluorescent reporter group and peptide recognition sequence. MV152 does not bind to the active site of the proteasomal catalytic subunit β, does not induce peptide-mediated elevation of 20S proteasome activity, and does not label the proteasomal catalytic subunit β in brain tissue homogenates. MV152 can be used as an inactive negative control in proteasome-related experiments.

For research use only. We do not sell to patients.

CAS No.: 945611-89-2
Formula: C₅₉H₉₃BF₂N₈O₉S
Molecular Weight:1139.29

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

MV152 Chemical Structure

CAS No.: 945611-89-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

In Vitro

MV152 does not label the active β subunits of purified human 20S proteasome^[1].
MV152 does not label the active β subunits of the proteasome in brain tissue homogenates^[1].
MV152 (10 min) does not alter the chymotrypsin-like activity of purified 20S proteasome under the experimental conditions^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 945611-89-2
Molecular Weight 1139.29
Formula C₅₉H₉₃BF₂N₈O₉S
SMILES

O=C(CCC1=C(C)[N-]2[B+3]([F-])([F-])[N]3=C(C4=CC=C(OC)C=C4)C=CC3=CC2=C1C)NCCCCCC(NCCCCCC(NCCCCCC(NC(CC(C)C)C(NC(CC(C)C)C(NC(CC(C)C)CCS(=O)(C)=O)=O)=O)=O)=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Türker F, et al. Orthogonal approaches required to measure proteasome composition and activity in mammalian brain tissue. The Journal of biological chemistry. 2023 Jun;299(6):104811. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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