TNS2 - tensin 2 Gene

Also Known as C1TEN; TENC1; C1-TEN

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23371

About TNS2

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:53,046,991-53,064,379 (from NCBI)

This gene has 20 transcripts (splice variants), 114 orthologues and 1 paralogue. Ubiquitous expression in fat (RPKM 68.0), ovary (RPKM 31.0) and 23 other tissues.

Summary

The protein encoded by this gene belongs to the tensin family. Tensin is a focal adhesion molecule that binds to actin filaments and participates in signaling pathways. This protein plays a role in regulating cell migration. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

TNS2 Products (3)

mRNA Protein Name
NM_015319.2 NP_056134.2 tensin-2 isoform 1
NM_170754.4 NP_736610.2 tensin-2 isoform 2
NM_198316.2 NP_938072.1 tensin-2 isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables kinase binding IPI
IPI: Inferred from physical interaction
22019427 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16273093 GOA
enables protein tyrosine phosphatase activity IDA
IDA: Inferred from direct assay
23401856 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
16951145 GOA
involved in negative regulation of insulin receptor signaling pathway IDA
IDA: Inferred from direct assay
23401856 GOA
involved in peptidyl-tyrosine dephosphorylation IDA
IDA: Inferred from direct assay
23401856 GOA
Cellular Component GO Annotation Evidence References Source
located in focal adhesion IDA
IDA: Inferred from direct assay
16951145 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNS2 Protein Structure

PTEN_C2

PTEN_C2: C2 domain of PTEN tumour-suppressor protein (297 - 423)

SH2

SH2: SH2 domain (1140 - 1232)

PTB

PTB: Phosphotyrosine-binding domain (1275 - 1408)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1409 a.a.
Protein Preferred Names Protein Names

tensin-2

  • C1 domain-containing phosphatase and tensin homolog

TNS2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TNS2 Q63HR2 KRTAP10-8 Homo sapiens P60410
Validated Y2H
25416956
Intra
TNS2 Q63HR2 KRTAP10-8 Homo sapiens P60410
Y2H Array
25416956
Intra
TNS2 Q63HR2 KRTAP10-5 Homo sapiens P60370
Validated Y2H
25416956
Intra
TNS2 Q63HR2 KRTAP10-5 Homo sapiens P60370
Y2H Array
25416956
Intra
TNS2 Q63HR2 KRTAP10-7 Homo sapiens P60409
Validated Y2H
25416956
Intra
TNS2 Q63HR2 KRTAP10-7 Homo sapiens P60409
Y2H Array
25416956
Intra
TNS2 Q63HR2 KRTAP10-7 Homo sapiens P60409
Y2H Prey Pooling
25416956
Intra
TNS2 Q63HR2 KRTAP12-2 Homo sapiens P59991
Y2H Prey Pooling
32296183
Intra
TNS2 Q63HR2 KRTAP12-2 Homo sapiens P59991
Y2H Array
25416956
Intra
TNS2 Q63HR2 KRTAP12-2 Homo sapiens P59991
Y2H Array
32296183
Intra
TNS2 Q63HR2 ZNF250 Homo sapiens P15622-3
Y2H Prey Pooling
25416956
Intra
TNS2 Q63HR2 ZNF250 Homo sapiens P15622-3
Validated Y2H
25416956
Intra
TNS2 Q63HR2 ZNF250 Homo sapiens P15622-3
Y2H Array
25416956
Intra
TNS2 Q63HR2 LUZP4 Homo sapiens Q9P127
Y2H Prey Pooling
32296183
Intra
TNS2 Q63HR2 LUZP4 Homo sapiens Q9P127
Validated Y2H
32296183
Intra
TNS2 Q63HR2 LUZP4 Homo sapiens Q9P127
Y2H Array
32296183
Intra
TNS2 Q63HR2 TEKT5 Homo sapiens Q96M29
Y2H Prey Pooling
32296183
Intra
TNS2 Q63HR2 TEKT5 Homo sapiens Q96M29
Y2H Prey Pooling
25416956
Intra
TNS2 Q63HR2 TEKT5 Homo sapiens Q96M29
Validated Y2H
32296183
Intra
TNS2 Q63HR2 TEKT5 Homo sapiens Q96M29
Y2H Array
32296183
Intra
TNS2 Q63HR2 q9nwl9_human Homo sapiens Q9NWL9
Validated Y2H
25416956
Intra
TNS2 Q63HR2 MET Homo sapiens P08581
FPS
24728074
Intra
TNS2 Q63HR2 ZNF497 Homo sapiens Q6ZNH5
Y2H Prey Pooling
32296183
Intra
TNS2 Q63HR2 ZNF497 Homo sapiens Q6ZNH5
Validated Y2H
32296183
Intra
TNS2 Q63HR2 ZNF497 Homo sapiens Q6ZNH5
Y2H Array
32296183
Intra
TNS2 Q63HR2 NUBP2 Homo sapiens Q9Y5Y2
Validated Y2H
25416956
Intra
TNS2 Q63HR2 NUBP2 Homo sapiens Q9Y5Y2
Y2H Array
25416956
Intra
TNS2 Q63HR2 KRTAP11-1 Homo sapiens Q8IUC1
Y2H Prey Pooling
32296183
Intra
TNS2 Q63HR2 KRTAP11-1 Homo sapiens Q8IUC1
Y2H Array
32296183
Intra
TNS2 Q63HR2 KRTAP11-1 Homo sapiens Q8IUC1
Validated Y2H
32296183
Intra
TNS2 Q63HR2 SUSD2 Homo sapiens Q9UGT4
Validated Y2H
32296183
Intra
TNS2 Q63HR2 KPRP Homo sapiens Q5T749
Y2H Prey Pooling
32296183
Intra
TNS2 Q63HR2 KPRP Homo sapiens Q5T749
BFG-2H
27107012
Intra
TNS2 Q63HR2 KPRP Homo sapiens Q5T749
Y2H Array
32296183
Intra
TNS2 Q63HR2 KPRP Homo sapiens Q5T749
Validated Y2H
27107012
Intra
TNS2 Q63HR2 PATZ1 Homo sapiens Q9HBE1-4
Validated Y2H
32296183
Intra
TNS2 Q63HR2 CPSF7 Homo sapiens Q8N684-3
Validated Y2H
32296183
Intra
TNS2 Q63HR2 CPSF7 Homo sapiens Q8N684-3
Y2H Array
32296183
Intra
TNS2 Q63HR2 CPSF7 Homo sapiens Q8N684-3
Y2H Prey Pooling
32296183
Intra
TNS2 Q63HR2 KRTAP1-3 Homo sapiens Q8IUG1
BFG-2H
27107012
Intra
TNS2 Q63HR2 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Array
32296183
Intra
TNS2 Q63HR2 KRTAP1-3 Homo sapiens Q8IUG1
Validated Y2H
27107012
Intra
TNS2 Q63HR2 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Prey Pooling
32296183
Intra
TNS2 Q63HR2 TFAP2D Homo sapiens Q7Z6R9
Validated Y2H
32296183
Intra
TNS2 Q63HR2 KRTAP12-3 Homo sapiens P60328
Y2H Array
32296183
Intra
TNS2 Q63HR2 KRTAP12-3 Homo sapiens P60328
Y2H Prey Pooling
32296183
Intra
TNS2 Q63HR2 KRTAP13-2 Homo sapiens Q52LG2
Y2H Array
32296183
Intra
TNS2 Q63HR2 KRTAP13-2 Homo sapiens Q52LG2
Y2H Prey Pooling
32296183
Intra
TNS2 Q63HR2 KRTAP4-4 Homo sapiens Q9BYR3
Y2H Prey Pooling
32296183
Intra
TNS2 Q63HR2 KRTAP4-4 Homo sapiens Q9BYR3
Y2H Array
32296183
Intra
TNS2 Q63HR2 KRTAP4-4 Homo sapiens Q9BYR3
Validated Y2H
32296183
Intra
TNS2 Q63HR2 ZNF837 Homo sapiens Q96EG3
Validated Y2H
32296183
Intra
TNS2 Q63HR2 ZIM2 Homo sapiens Q9NZV7
Validated Y2H
32296183
Intra
TNS2 Q63HR2 ZIM2 Homo sapiens Q9NZV7
Y2H Prey Pooling
32296183
Intra
TNS2 Q63HR2 USP54 Homo sapiens Q70EL1-9
Y2H Prey Pooling
32296183
Intra
TNS2 Q63HR2 USP54 Homo sapiens Q70EL1-9
Validated Y2H
32296183
Intra
TNS2 Q63HR2 USP54 Homo sapiens Q70EL1-9
Y2H Array
32296183
Intra
TNS2 Q63HR2 LMNTD2 Homo sapiens Q8IXW0
Validated Y2H
32296183
Intra
TNS2 Q63HR2 SLC25A48 Homo sapiens Q6ZT89-3
Validated Y2H
32296183
Intra
TNS2 Q63HR2 RBAK Homo sapiens Q9NYW8
Y2H Array
32296183
Intra
TNS2 Q63HR2 RBAK Homo sapiens Q9NYW8
Y2H Prey Pooling
32296183
Intra
TNS2 Q63HR2 RBAK Homo sapiens Q9NYW8
Validated Y2H
32296183
Intra
TNS2 Q63HR2 FAM228A Homo sapiens Q86W67
Y2H Prey Pooling
32296183
Intra
TNS2 Q63HR2 FAM228A Homo sapiens Q86W67
Validated Y2H
32296183
Intra
TNS2 Q63HR2 FAM228A Homo sapiens Q86W67
Y2H Array
32296183
Intra
TNS2 Q63HR2 KIT Homo sapiens P10721
FPS
24728074
Intra
TNS2 Q63HR2 ZNF575 Homo sapiens Q86XF7
Validated Y2H
32296183
Intra
TNS2 Q63HR2 SOCS7 Homo sapiens O14512
Y2H Array
32296183
Intra
TNS2 Q63HR2 SOCS7 Homo sapiens O14512
Y2H Prey Pooling
32296183
Intra
TNS2 Q63HR2 ZNF134 Homo sapiens P52741
Y2H Prey Pooling
32296183
Intra
TNS2 Q63HR2 ZNF134 Homo sapiens P52741
Y2H Array
32296183
Intra
TNS2 Q63HR2 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
Intra
TNS2 Q63HR2 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
Intra
TNS2 Q63HR2 KRTAP6-3 Homo sapiens Q3LI67
Y2H Prey Pooling
32296183
Intra
TNS2 Q63HR2 KRTAP6-3 Homo sapiens Q3LI67
Y2H Array
32296183
Intra
TNS2 Q63HR2 TRIM8 Homo sapiens Q9BZR9
Y2H Prey Pooling
32296183
Intra
TNS2 Q63HR2 TRIM8 Homo sapiens Q9BZR9
Y2H Array
32296183
Intra
TNS2 Q63HR2 TRIM8 Homo sapiens Q9BZR9
Validated Y2H
32296183
Intra
TNS2 Q63HR2 PKP1 Homo sapiens Q13835
Validated Y2H
25416956
Intra
TNS2 Q63HR2 PKP1 Homo sapiens Q13835
Y2H Array
25416956
Intra
TNS2 Q63HR2 BLZF1 Homo sapiens Q9H2G9
Validated Y2H
32296183
Intra
TNS2 Q63HR2 BLZF1 Homo sapiens Q9H2G9
Y2H Array
32296183
Intra
TNS2 Q63HR2 BLZF1 Homo sapiens Q9H2G9
Y2H Prey Pooling
32296183
Intra
TNS2 Q63HR2 SERTAD2 Homo sapiens Q14140
Y2H Array
32296183
Intra
TNS2 Q63HR2 SERTAD2 Homo sapiens Q14140
Y2H Prey Pooling
32296183
Intra
TNS2 Q63HR2 MYPOP Homo sapiens Q86VE0
Validated Y2H
32296183
Intra
TNS2 Q63HR2 MYPOP Homo sapiens Q86VE0
Y2H Array
32296183
Intra
TNS2 Q63HR2 KRT76 Homo sapiens Q01546
Y2H Array
32296183
Intra
TNS2 Q63HR2 KRT76 Homo sapiens Q01546
Y2H Prey Pooling
32296183
Intra
TNS2 Q63HR2 REL Homo sapiens Q04864
Validated Y2H
25416956
Intra
TNS2 Q63HR2 REL Homo sapiens Q04864
Y2H Array
25416956
Intra
TNS2 Q63HR2 REL Homo sapiens Q04864
Y2H Prey Pooling
25416956
Intra
TNS2 Q63HR2 ZCCHC14 Homo sapiens Q8WYQ9
Y2H Prey Pooling
32296183
Intra
TNS2 Q63HR2 ZCCHC14 Homo sapiens Q8WYQ9
Validated Y2H
32296183
Intra
TNS2 Q63HR2 ZCCHC14 Homo sapiens Q8WYQ9
Y2H Array
32296183
Intra
TNS2 Q63HR2 FADS6 Homo sapiens Q8N9I5
Validated Y2H
32296183
Intra
TNS2 Q63HR2 KCTD9 Homo sapiens Q7L273
Validated Y2H
32296183
Intra
TNS2 Q63HR2 KCTD9 Homo sapiens Q7L273
Y2H Prey Pooling
32296183
Intra
TNS2 Q63HR2 KCTD9 Homo sapiens Q7L273
Y2H Array
32296183
Intra
TNS2 Q63HR2 ERBB2 Homo sapiens P04626
Protein Array
16273093
Intra
TNS2 Q63HR2 ZNF587 Homo sapiens Q96SQ5
Validated Y2H
32296183
Intra
TNS2 Q63HR2 ZNF587 Homo sapiens Q96SQ5
Validated Y2H
25416956
Intra
TNS2 Q63HR2 ZNF587 Homo sapiens Q96SQ5
Y2H Prey Pooling
25416956
Intra
TNS2 Q63HR2 ZNF587 Homo sapiens Q96SQ5
Y2H Array
25416956
Intra
TNS2 Q63HR2 ZNF587 Homo sapiens Q96SQ5
Y2H Prey Pooling
32296183
Intra
TNS2 Q63HR2 ZNF587 Homo sapiens Q96SQ5
Y2H Array
32296183
Intra
TNS2 Q63HR2 INO80B Homo sapiens Q9C086
Validated Y2H
32296183
Intra
TNS2 Q63HR2 ERBB3 Homo sapiens P21860
Protein Array
16273093
Intra
TNS2 Q63HR2 C22orf39 Homo sapiens Q6P5X5
Validated Y2H
32296183
Intra
TNS2 Q63HR2 OTX1 Homo sapiens P32242
BFG-2H
27107012
Intra
TNS2 Q63HR2 OTX1 Homo sapiens P32242
Y2H Array
32296183
Intra
TNS2 Q63HR2 OTX1 Homo sapiens P32242
Validated Y2H
27107012
Intra
TNS2 Q63HR2 OTX1 Homo sapiens P32242
Y2H Prey Pooling
32296183
Intra
TNS2 Q63HR2 ZNF417 Homo sapiens Q8TAU3
Validated Y2H
32296183
Intra
TNS2 Q63HR2 ZNF417 Homo sapiens Q8TAU3
Y2H Array
25416956
Intra
TNS2 Q63HR2 ZNF417 Homo sapiens Q8TAU3
Y2H Array
32296183
Intra
TNS2 Q63HR2 ZNF417 Homo sapiens Q8TAU3
Y2H Prey Pooling
25416956
Intra
TNS2 Q63HR2 ZNF417 Homo sapiens Q8TAU3
Y2H Prey Pooling
32296183
Intra
TNS2 Q63HR2 HOXA1 Homo sapiens P49639
Y2H Prey Pooling
32296183
Intra
TNS2 Q63HR2 HOXA1 Homo sapiens P49639
Y2H Array
32296183
Intra
TNS2 Q63HR2 CNNM3 Homo sapiens Q8NE01
Validated Y2H
32296183
Intra
TNS2 Q63HR2 SORBS3 Homo sapiens O60504
Y2H Array
32296183
Intra
TNS2 Q63HR2 SORBS3 Homo sapiens O60504
Y2H Prey Pooling
32296183
Intra
TNS2 Q63HR2 BAHD1 Homo sapiens Q8TBE0
Validated Y2H
32296183
Intra
TNS2 Q63HR2 RAMAC Homo sapiens Q9BTL3
Validated Y2H
32296183
Intra
TNS2 Q63HR2 ENKD1 Homo sapiens Q9H0I2
Validated Y2H
32296183
Intra
TNS2 Q63HR2 ENKD1 Homo sapiens Q9H0I2
Y2H Array
32296183
Intra
TNS2 Q63HR2 ENKD1 Homo sapiens Q9H0I2
Y2H Prey Pooling
32296183
Intra
TNS2 Q63HR2 LPXN Homo sapiens O60711
Y2H Array
32296183
Intra
TNS2 Q63HR2 LPXN Homo sapiens O60711
Y2H Prey Pooling
32296183
Intra
TNS2 Q63HR2 CATSPER1 Homo sapiens Q8NEC5
Validated Y2H
32296183
Intra
TNS2 Q63HR2 ZNF205 Homo sapiens O95201
Y2H Prey Pooling
32296183
Intra
TNS2 Q63HR2 ZNF205 Homo sapiens O95201
Y2H Array
32296183
Intra
TNS2 Q63HR2 CRX Homo sapiens O43186
Y2H Prey Pooling
32296183
Intra
TNS2 Q63HR2 CRX Homo sapiens O43186
Y2H Array
32296183
Intra
TNS2 Q63HR2 REEP6 Homo sapiens Q96HR9
Y2H Prey Pooling
25416956
Intra
TNS2 Q63HR2 REEP6 Homo sapiens Q96HR9
Y2H Array
25416956
Intra
TNS2 Q63HR2 PLSCR3 Homo sapiens Q9NRY6
Y2H Array
32296183
Intra
TNS2 Q63HR2 PLSCR3 Homo sapiens Q9NRY6
Y2H Prey Pooling
32296183
Intra
TNS2 Q63HR2 PLSCR3 Homo sapiens Q9NRY6
Validated Y2H
32296183
Intra
TNS2 Q63HR2 TENT5B Homo sapiens Q96A09
Validated Y2H
32296183
Intra
TNS2 Q63HR2 CTSZ Homo sapiens Q9UBR2
Validated Y2H
32296183
Intra
TNS2 Q63HR2 TEKT3 Homo sapiens Q9BXF9
Y2H Prey Pooling
32296183
Intra
TNS2 Q63HR2 TEKT3 Homo sapiens Q9BXF9
Validated Y2H
32296183
Intra
TNS2 Q63HR2 TEKT3 Homo sapiens Q9BXF9
Y2H Array
32296183
Intra
TNS2 Q63HR2 LASP1 Homo sapiens Q14847-2
Y2H Prey Pooling
32296183
Intra
TNS2 Q63HR2 LASP1 Homo sapiens Q14847-2
Y2H Array
32296183
Intra
TNS2 Q63HR2 C1orf94 Homo sapiens Q6P1W5
Validated Y2H
32296183
Intra
TNS2 Q63HR2 C1orf94 Homo sapiens Q6P1W5
Y2H Array
32296183
Intra
TNS2 Q63HR2 C1orf94 Homo sapiens Q6P1W5
Y2H Prey Pooling
32296183
Intra
TNS2 Q63HR2 EPDR1 Homo sapiens Q9UM22
Validated Y2H
32296183
Intra
TNS2 Q63HR2 ARID5A Homo sapiens Q03989
Y2H Prey Pooling
32296183
Intra
TNS2 Q63HR2 ARID5A Homo sapiens Q03989
Y2H Array
32296183
Intra
TNS2 Q63HR2 DZIP3 Homo sapiens Q86Y13
Validated Y2H
32296183
Intra
TNS2 Q63HR2 DZIP3 Homo sapiens Q86Y13
Y2H Array
32296183
Intra
TNS2 Q63HR2 DZIP3 Homo sapiens Q86Y13
Y2H Prey Pooling
32296183
Intra
TNS2 Q63HR2 DZIP1 Homo sapiens Q86YF9
Y2H Prey Pooling
32296183
Intra
TNS2 Q63HR2 DZIP1 Homo sapiens Q86YF9
Validated Y2H
32296183
Intra
TNS2 Q63HR2 DZIP1 Homo sapiens Q86YF9
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Nephrotic Syndrome, Type 22

  • NPHS22

  • Nephrotic Syndrome Type 22

  • Nephrotic Syndrome 22
Epidermolysis Bullosa Simplex 5b, With Muscular Dystrophy

  • Epidermolysis Bullosa Simplex With Muscular Dystrophy

  • Md-Ebs

  • Epidermolysis Bullosa Simplex And Limb-Girdle Muscular Dystrophy

  • EBS5B

  • Ebsmd

  • Mdebs

  • Limb-Girdle Muscular Dystrophy With Epidermolysis Bullosa Simplex

  • Ebs-Md

  • Epidermolysa Bullosa Simplex And Limb Girdle Muscular Dystrophy

  • Epidermolysa Bullosa Simplex With Muscular Dystrophy

  • Epidermolysis Bullosa Simplex - Limb Girdle Muscular Dystrophy

  • Ebs With Muscular Dystrophy

  • Muscular Dystrophy With Epidermolysis Bullosa Simplex

  • Epidermolysa Bullosa Simplex, With Muscular Dystrophy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14868 TNS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta TNS2 VGNC VGNC:79199
Canis familiaris TNS2 VGNC VGNC:47702
Rattus norvegicus TNS2 RGD RGD:1310917
Bos taurus TNS2 VGNC VGNC:36208
Mus musculus TNS2 MGD MGI:2387586
Felis catus TNS2 VGNC VGNC:66436
Others TNS2 NCBI