RRP8 - ribosomal RNA processing 8 Gene

Also Known as NML; KIAA0409

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23378

About RRP8

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:6,595,072-6,603,616 (from NCBI)

This gene has 5 transcripts (splice variants) and 195 orthologues. Ubiquitous expression in spleen (RPKM 2.0), lymph node (RPKM 1.9) and 25 other tissues.

Summary

Enables methylated histone binding activity. Involved in several processes, including cellular response to glucose starvation; intrinsic apoptotic signaling pathway by p53 class mediator; and regulation of gene expression. Located in several cellular components, including cytosol; nuclear lumen; and rDNA heterochromatin. Part of chromatin silencing complex. [provided by Alliance of Genome Resources, Apr 2022]

RRP8 Products (1)

mRNA Protein Name
NM_015324.4 NP_056139.1 ribosomal RNA-processing protein 8

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables methylated histone binding IDA
IDA: Inferred from direct assay
18485871 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18485871 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to glucose starvation IMP
IMP: Inferred from mutant phenotype
18485871 GOA
involved in energy homeostasis IMP
IMP: Inferred from mutant phenotype
18485871 GOA
involved in intrinsic apoptotic signaling pathway by p53 class mediator IMP
IMP: Inferred from mutant phenotype
21471221 GOA
involved in negative regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
18485871 GOA
involved in negative regulation of cell cycle IMP
IMP: Inferred from mutant phenotype
18485871 GOA
involved in rDNA heterochromatin formation IDA
IDA: Inferred from direct assay
18485871 GOA
involved in rDNA heterochromatin formation IMP
IMP: Inferred from mutant phenotype
18485871 GOA
acts upstream of negative effect regulation of G1 to G0 transition IMP
IMP: Inferred from mutant phenotype
21471221 GOA
involved in regulation of transcription by glucose IMP
IMP: Inferred from mutant phenotype
18485871 GOA
Cellular Component GO Annotation Evidence References Source
part of chromatin silencing complex IDA
IDA: Inferred from direct assay
18485871 GOA
part of eNoSc complex IPI
IPI: Inferred from physical interaction
18485871 GOA
located in nucleolus IDA
IDA: Inferred from direct assay
18485871 GOA
located in rDNA heterochromatin IDA
IDA: Inferred from direct assay
18485871 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RRP8 Protein Structure

Methyltransf_8

Methyltransf_8: Hypothetical methyltransferase (238 - 456)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 456 a.a.
Protein Preferred Names Protein Names

ribosomal RNA-processing protein 8

  • RRP8 methyltransferase homolog

RRP8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RRP8 O43159 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra
RRP8 O43159 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
RRP8 O43159 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
RRP8 O43159 SIRT1 Homo sapiens Q96EB6
Anti Tag CoIP
18485871
Intra
RRP8 O43159 SIRT1 Homo sapiens Q96EB6
Anti Bait CoIP
18485871
Intra
RRP8 O43159 SUV39H1 Homo sapiens O43463
Anti Bait CoIP
18485871
Intra
RRP8 O43159 SUV39H1 Homo sapiens O43463
Anti Tag CoIP
18485871
Intra
RRP8 O43159 DVL3 Homo sapiens Q92997
Y2H Prey Pooling
32296183
Intra
RRP8 O43159 DVL3 Homo sapiens Q92997
Validated Y2H
32296183
Intra
RRP8 O43159 DVL3 Homo sapiens Q92997
Y2H Array
32296183
Intra
RRP8 O43159 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Intra
RRP8 O43159 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Intra
RRP8 O43159 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12292 RRP8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus RRP8 VGNC VGNC:64782
Rattus norvegicus RRP8 RGD RGD:1308302
Canis familiaris RRP8 VGNC VGNC:52288
Macaca mulatta RRP8 VGNC VGNC:77120
Bos taurus RRP8 VGNC VGNC:34171
Mus musculus RRP8 MGD MGI:1914251
Others RRP8 NCBI