Inpp5d - inositol polyphosphate-5-phosphatase D Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 54259

Summary

Enables inositol-4,5-bisphosphate 5-phosphatase activity. Predicted to be involved in apoptotic process and phosphatidylinositol dephosphorylation. Predicted to act upstream of or within several processes, including negative regulation of B cell proliferation; negative regulation of bone resorption; and regulation of hemopoiesis. Located in actin filament; cortical cytoskeleton; and cytosol. Colocalizes with plasma membrane. Orthologous to human INPP5D (inositol polyphosphate-5-phosphatase D). [provided by Alliance of Genome Resources, Apr 2022]

Inpp5d Products (1)

mRNA Protein Name
NM_019311.2 NP_062184.2 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables inositol-4,5-bisphosphate 5-phosphatase activity IDA
IDA: Inferred from direct assay
11714805 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
15661894 RGD
Cellular Component GO Annotation Evidence References Source
located in actin filament IDA
IDA: Inferred from direct assay
15661894 RGD
located in cortical cytoskeleton IDA
IDA: Inferred from direct assay
15661894 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

  • Inositol polyphosphate-5-phosphatase, 145 kDa

  • SH2 domain-containing inositol 5'-phosphatase 1

  • SH2 domain-containing inositol phosphatase 1

  • SHIP-1

  • phosphatidylinositol-4,5-bisphosphate 5-phosphatase

Inpp5d Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Inpp5d P97573 TRIP10 Homo sapiens Q15642-1
Pull Down
26751515
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS21142 Inpp5d Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06829 INPP5D Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27659 Inpp5d Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Inpp5d NCBI NCBI:3635