INTS10 - integrator complex subunit 10 Gene

Also Known as INT10; C8orf35

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55174

About INTS10

Cytogenetic location: 8p21.3 Genomic coordinates (GRCh38): 8:19,817,416-19,852,067 (from NCBI)

This gene has 19 transcripts (splice variants) and 205 orthologues. Ubiquitous expression in thyroid (RPKM 19.2), prostate (RPKM 12.2) and 25 other tissues.

Summary

INTS10 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]

INTS10 Products (19)

mRNA	Protein	Name
NM_001353505.2	NP_001340434.1	integrator complex subunit 10 isoform a
NM_001353506.2	NP_001340435.1	integrator complex subunit 10 isoform b
NM_001353507.2	NP_001340436.1	integrator complex subunit 10 isoform c
NM_001353508.2	NP_001340437.1	integrator complex subunit 10 isoform d
NM_001353509.2	NP_001340438.1	integrator complex subunit 10 isoform e
NM_001353510.2	NP_001340439.1	integrator complex subunit 10 isoform f
NM_001353511.2	NP_001340440.1	integrator complex subunit 10 isoform h
NM_001353512.2	NP_001340441.1	integrator complex subunit 10 isoform i
NM_001353513.2	NP_001340442.1	integrator complex subunit 10 isoform j
NM_001353514.2	NP_001340443.1	integrator complex subunit 10 isoform k
NM_001353515.2	NP_001340444.1	integrator complex subunit 10 isoform l
NM_001353516.2	NP_001340445.1	integrator complex subunit 10 isoform m
NM_001353517.2	NP_001340446.1	integrator complex subunit 10 isoform n
NM_001353518.2	NP_001340447.1	integrator complex subunit 10 isoform n
NM_001353519.2	NP_001340448.1	integrator complex subunit 10 isoform n
NM_001353520.2	NP_001340449.1	integrator complex subunit 10 isoform o
NM_001353521.2	NP_001340450.1	integrator complex subunit 10 isoform p
NM_001353522.2	NP_001340451.1	integrator complex subunit 10 isoform p
NM_018142.4	NP_060612.2	integrator complex subunit 10 isoform g

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
contributes to protein binding	IPI IPI: Inferred from physical interaction	16239144	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	24981860	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in snRNA processing	IDA IDA: Inferred from direct assay	16239144	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of integrator complex	IDA IDA: Inferred from direct assay	16239144	GOA
located in nucleus	IDA IDA: Inferred from direct assay	23904267	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
integrator complex subunit 10

INTS10 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	INTS10	Q9NVR2	NECAB2	Homo sapiens	Q7Z6G3-2	Y2H Prey Pooling	32296183
Intra	INTS10	Q9NVR2	NECAB2	Homo sapiens	Q7Z6G3-2	Y2H Array	32296183
Intra	INTS10	Q9NVR2	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	INTS10	Q9NVR2	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	INTS10	Q9NVR2	INTS14	Homo sapiens	Q96SY0	GMS	33548203
Intra	INTS10	Q9NVR2	INTS14	Homo sapiens	Q96SY0	Anti Tag CoIP	33961781
Intra	INTS10	Q9NVR2	INTS14	Homo sapiens	Q96SY0	TAP	24981860
Intra	INTS10	Q9NVR2	INTS14	Homo sapiens	Q96SY0	GMS	32647223
Intra	INTS10	Q9NVR2	INTS14	Homo sapiens	Q96SY0	Anti Tag CoIP	28514442
Intra	INTS10	Q9NVR2	INTS14	Homo sapiens	Q96SY0	Pull Down	33548203
Intra	INTS10	Q9NVR2	ZNF655	Homo sapiens	Q8N720	Y2H Prey Pooling	32296183
Intra	INTS10	Q9NVR2	ZNF655	Homo sapiens	Q8N720	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Kbg Syndrome	KBGS Macrodontia, Mental Retardation, Characteristic Facies, Short Stature, And Skeletal Anomalies Short Stature, Characteristic Facies, Macrodontia, Intellectual Disability, And Skeletal Anomalies Short Stature, Characteristic Facies, Macrodontia, Mental Retardation, And Skeletal Anomalies Short Stature-Characteristic Facies-Mental Retardation-Macrodontia-Skeletal Anomalies Syndrome Short Stature-Facial And Skeletal Anomalies-Intellectual Disability-Macrodontia Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06851	INTS10 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	INTS10	VGNC	VGNC:30224
Felis catus	INTS10	VGNC	VGNC:62938
Mus musculus	INTS10	MGD	MGI:1918135
Rattus norvegicus	INTS10	RGD	RGD:1304711
Macaca mulatta	INTS10	VGNC	VGNC:73653
Canis familiaris	INTS10	VGNC	VGNC:42046
Others	INTS10	NCBI