INTS10 - integrator complex subunit 10 Gene

Homo sapiens

Also known as INT10; C8orf35

Gene ID: 55174 | Gene type: protein coding

About INTS10

Cytogenetic location: 8p21.3 Genomic coordinates (GRCh38): 8:19,817,416-19,852,067 (from NCBI)

This gene has 19 transcripts (splice variants) and 205 orthologues. Ubiquitous expression in thyroid (RPKM 19.2), prostate (RPKM 12.2) and 25 other tissues.

Summary

INTS10 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]

INTS10 Products(19)

mRNA	Protein	Name
NM_001353505.2	NP_001340434.1	integrator complex subunit 10 isoform a
NM_001353506.2	NP_001340435.1	integrator complex subunit 10 isoform b
NM_001353507.2	NP_001340436.1	integrator complex subunit 10 isoform c
NM_001353508.2	NP_001340437.1	integrator complex subunit 10 isoform d
NM_001353509.2	NP_001340438.1	integrator complex subunit 10 isoform e
NM_001353510.2	NP_001340439.1	integrator complex subunit 10 isoform f
NM_001353511.2	NP_001340440.1	integrator complex subunit 10 isoform h
NM_001353512.2	NP_001340441.1	integrator complex subunit 10 isoform i
NM_001353513.2	NP_001340442.1	integrator complex subunit 10 isoform j
NM_001353514.2	NP_001340443.1	integrator complex subunit 10 isoform k
NM_001353515.2	NP_001340444.1	integrator complex subunit 10 isoform l
NM_001353516.2	NP_001340445.1	integrator complex subunit 10 isoform m
NM_001353517.2	NP_001340446.1	integrator complex subunit 10 isoform n
NM_001353518.2	NP_001340447.1	integrator complex subunit 10 isoform n
NM_001353519.2	NP_001340448.1	integrator complex subunit 10 isoform n
NM_001353520.2	NP_001340449.1	integrator complex subunit 10 isoform o
NM_001353521.2	NP_001340450.1	integrator complex subunit 10 isoform p
NM_001353522.2	NP_001340451.1	integrator complex subunit 10 isoform p
NM_018142.4	NP_060612.2	integrator complex subunit 10 isoform g

Protein Preferred Names

Protein Names

integrator complex subunit 10

Related Diseases

Diseases

Alias

Kbg Syndrome

KBGS	Macrodontia, Mental Retardation, Characteristic Facies, Short Stature, And Skeletal Anomalies
Short Stature, Characteristic Facies, Macrodontia, Intellectual Disability, And Skeletal Anomalies	Short Stature, Characteristic Facies, Macrodontia, Mental Retardation, And Skeletal Anomalies
Short Stature-Characteristic Facies-Mental Retardation-Macrodontia-Skeletal Anomalies Syndrome	Short Stature-Facial And Skeletal Anomalies-Intellectual Disability-Macrodontia Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06851	INTS10 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	INTS10	VGNC	VGNC:30224
Felis catus	INTS10	VGNC	VGNC:62938
Mus musculus	INTS10	MGD	MGI:1918135
Rattus norvegicus	INTS10	RGD	RGD:1304711
Macaca mulatta	INTS10	VGNC	VGNC:73653
Canis familiaris	INTS10	VGNC	VGNC:42046

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