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INTS14 - integrator complex subunit 14 Gene

Also Known as VWA9; C15orf44

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 81556

About INTS14

This gene has 18 transcripts (splice variants) and 205 orthologues. Ubiquitous expression in thyroid (RPKM 12.8), testis (RPKM 11.6) and 25 other tissues.

Summary

Predicted to be involved in snRNA 3'-end processing. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

INTS14 Products (10)

mRNA	Protein	Name
NM_001136043.3	NP_001129515.1	integrator complex subunit 14 isoform 1
NM_001207058.3	NP_001193987.2	integrator complex subunit 14 isoform 4
NM_001207059.3	NP_001193988.2	integrator complex subunit 14 isoform 1
NM_001366360.2	NP_001353289.1	integrator complex subunit 14 isoform 2
NM_001366364.2	NP_001353293.1	integrator complex subunit 14 isoform 1
NM_001366365.2	NP_001353294.1	integrator complex subunit 14 isoform 1
NM_001394794.1	NP_001381723.1	integrator complex subunit 14 isoform 2
NM_001394795.1	NP_001381724.1	integrator complex subunit 14 isoform 3
NM_001394796.1	NP_001381725.1	integrator complex subunit 14 isoform 2
NM_001394797.1	NP_001381726.1	integrator complex subunit 14 isoform 5

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	24981860	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

INTS14 Protein Structure

VWA_2

0
100
200
300
400
518 a.a.

Protein Preferred Names	Protein Names
integrator complex subunit 14	UPF0464 protein C15orf44

INTS14 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	INTS14	Q96SY0	INTS10	Homo sapiens	Q9NVR2	Pull Down	32647223
Intra	INTS14	Q96SY0	INTS10	Homo sapiens	Q9NVR2	Anti Tag CoIP	26496610
Intra	INTS14	Q96SY0	INTS13	Homo sapiens	Q9NVM9	Anti Tag CoIP	26496610
Intra	INTS14	Q96SY0	INTS13	Homo sapiens	Q9NVM9	Pull Down	32647223

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Folic Acid Deficiency Anemia	Folate Deficiency Anaemia Folic Acid Deficiency Anaemia Folate Deficiency Anemia Folate-Deficiency Anaemia Folate-Deficiency Anemia Folate-Deficient Megaloblastic Anaemia Megaloblastic Anemia Due To Folate Deficiency Anaemia Of Folate Deficiency Folate Or Folic Acid Deficiency Anaemia Nos Folic Acid Deficiency Anaemia Nos Acquired Megaloblastic Anaemia Due To Nutritional Folate Deficiency Dietary Folic Acid Deficiency Anaemia Dietary Folate Deficiency Anaemia Folate Deficiency Anaemia Due To Dietary Causes Goat'S Milk Anaemia Acquired Megaloblastic Anaemia Due To Folate Deficiency Secondary To Increased Requirement Megaloblastic Anaemia Due To Increased Requirements Of Folate Acquired Megaloblastic Anaemia Due To Folate Deficiency Secondary To Intestinal Disorders Acquired Megaloblastic Anaemia Due To Decreased Intestinal Absorption Of Folate Megaloblastic Anaemia Due To Decreased Intestinal Absorption Of Folate
Short-Rib Thoracic Dysplasia 4 With Or Without Polydactyly	Asphyxiating Thoracic Dystrophy 4 SRTD4 Atd4 Jatd Jeune Asphyxiating Thoracic Dystrophy Jeune Syndrome 4

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06853	INTS14 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	INTS14	VGNC	VGNC:30227
Macaca mulatta	INTS14	VGNC	VGNC:73650
Canis familiaris	INTS14	VGNC	VGNC:42050
Felis catus	INTS14	VGNC	VGNC:62942
Rattus norvegicus	INTS14	RGD	RGD:1359616
Mus musculus	INTS14	MGD	MGI:1917132
Others	INTS14	NCBI