SMOC2 - SPARC related modular calcium binding 2 Gene

Also Known as DTDP1; SMAP2; MST117; MSTP117; MSTP140; bA37D8.1; bA270C4A.1; dJ421D16.1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64094

About SMOC2

Cytogenetic location: 6q27 Genomic coordinates (GRCh38): 6:168,441,184-168,667,992 (from NCBI)

This gene has 5 transcripts (splice variants), 205 orthologues, 1 paralogue and is associated with 3 phenotypes. Broad expression in endometrium (RPKM 68.7), gall bladder (RPKM 54.9) and 18 other tissues.

Summary

This gene encodes a member of the SPARC family (secreted protein acidic and rich in cysteine/osteonectin/BM-40), which are highly expressed during embryogenesis and wound healing. The gene product is a matricellular protein which promotes matrix assembly and can stimulate endothelial cell proliferation and migration, as well as angiogenic activity. Associated with pulmonary function, this secretory gene product contains a Kazal domain, two thymoglobulin type-1 domains, and two EF-hand calcium-binding domains. The encoded protein may serve as a target for controlling angiogenesis in tumor growth and myocardial ischemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

SMOC2 Products (2)

mRNA Protein Name
NM_001166412.2 NP_001159884.1 SPARC-related modular calcium-binding protein 2 isoform 2 precursor
NM_022138.3 NP_071421.1 SPARC-related modular calcium-binding protein 2 isoform 1 precursor

SMOC2 Protein Structure

Kazal_2

Kazal_2: Kazal-type serine protease inhibitor domain (48 - 84)

Thyroglobulin_1

Thyroglobulin_1: Thyroglobulin type-1 repeat (90 - 153)

Thyroglobulin_1

Thyroglobulin_1: Thyroglobulin type-1 repeat (216 - 281)

SPARC_Ca_bdg

SPARC_Ca_bdg: Secreted protein acidic and rich in cysteine Ca binding region (303 - 412)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 446 a.a.
Protein Preferred Names Protein Names

SPARC-related modular calcium-binding protein 2

  • SMAP-2

SMOC2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SMOC2 Q9H3U7 KRTAP5-1 Homo sapiens Q6L8H4
Y2H Array
32296183
Intra
SMOC2 Q9H3U7 KRTAP5-1 Homo sapiens Q6L8H4
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

SMOC2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P87077 SMOC2 Antibody (YA6770) WB, IHC-P Human, Mouse, Rat

Related Diseases

Diseases Alias
Dentin Dysplasia, Type I

  • Radicular Dentin Dysplasia

  • DTDP1

  • Rootless Teeth

  • Dentin Dysplasia Type I

  • Dd-I

  • Dentin Dysplasia Shields Type I

  • Dentin Dysplasia, Shields Type I

  • Dentin Dysplasia, Type I, With Microdontia And Misshapen Teeth

  • Dentin Dysplasia, Type 1

  • Atypical Dentin Dysplasia Due To Smoc2 Deficiency

  • Dentin Dysplasia Type 1 With Microdontia And Shape Anomalies

  • Dentin Dysplasia, Radicular

  • Dentin Dysplasia 1

  • Dentin Dysplasia 1, With Extreme Microdontia And Misshapen Teeth

  • DTDP1-MMT

  • Dentin Dysplasia, Type I, With Extreme Microdontia And Misshapen Teeth

  • Dysplasia, Dentin, Type I
Dentin Dysplasia

  • Dentinal Dysplasia

  • Dd

  • Dysplasia, Dentin

  • Shell Teeth
Gender Incongruence

  • Gender Dysphoria

  • Transsexualism

  • Gender Identify Disorder
Gastric Cancer

  • Stomach Cancer

  • Gastric Carcinoma

  • Stomach Carcinoma

  • Gastric Cancer, Somatic

  • Gastric Neoplasm

  • Carcinoma Of Stomach

  • Stomach Neoplasms

  • Malignant Neoplasm Of Stomach

  • Gastric Cancer Risk After H. Pylori Infection

  • Cancer Of The Stomach

  • Adult Stomach Cancer

  • Adult Stomach Carcinoma

  • GASC

  • Gastric Cancer Intestinal

  • Gastric Cancers

  • Gastric Carcinomas

  • Cancer, Gastric

  • Stomach Neoplasm

  • Malignant Neoplasm Of Body Of Stomach

  • Malignant Tumor Of Lesser Curve Of Stomach

  • Gastrocarcinoma Of Unspecified Site

  • Leather Bottle Stomach

  • Carcinoma Of Fundus Of Stomach

  • Cancer Of Fundus Of Stomach

  • Primary Malignant Neoplasm Of Body Of Stomach

  • Cancer Of Body Of Stomach

  • Primary Malignant Neoplasm Of Pyloric Antrum

  • Pyloric Antrum Cancer

  • Malignant Tumour Of Stomach
Tooth Agenesis

  • Oligodontia

  • Hypodontia

  • Selective Tooth Agenesis

  • Tooth Agenesis, Selective

  • Familial Tooth Agenesis

  • Anodontia

  • Congenital Absence Of One Tooth
Nanophthalmos

  • Nanophthalmia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13445 SMOC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SMOC2 VGNC VGNC:65499
Mus musculus SMOC2 MGD MGI:1929881
Rattus norvegicus SMOC2 RGD RGD:1306681
Bos taurus SMOC2 VGNC VGNC:35027
Canis familiaris SMOC2 VGNC VGNC:46567
Macaca mulatta SMOC2 VGNC VGNC:83470
Others SMOC2 NCBI