Rtf1 - RTF1, Paf1/RNA polymerase II complex component Gene

Also Known as Gtl7; cbp82; 2900005O08Rik; 6530416A09Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 76246

Summary

Predicted to enable RNA polymerase II C-terminal domain phosphoserine binding activity and single-stranded DNA binding activity. Involved in several processes, including endodermal cell fate commitment; histone H3-K4 trimethylation; and positive regulation of histone H3-K4 methylation. Acts upstream of or within blastocyst growth. Located in nucleolus. Part of Cdc73/Paf1 complex. Is expressed in several structures, including brain and retina nuclear layer. Orthologous to human RTF1 (RTF1 homolog, Paf1/RNA polymerase II complex component). [provided by Alliance of Genome Resources, Apr 2022]

Rtf1 Products (1)

mRNA Protein Name
NM_030112.2 NP_084388.2 RNA polymerase-associated protein RTF1 homolog precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
contributes to protein binding IPI
IPI: Inferred from physical interaction
27749823 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within blastocyst growth IMP
IMP: Inferred from mutant phenotype
24036311 MGI
involved in chromatin organization IMP
IMP: Inferred from mutant phenotype
19345177 MGI
involved in endodermal cell fate commitment IMP
IMP: Inferred from mutant phenotype
19345177 MGI
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
19345177 MGI
involved in stem cell population maintenance IMP
IMP: Inferred from mutant phenotype
19345177 MGI
Cellular Component GO Annotation Evidence References Source
part of Cdc73/Paf1 complex IPI
IPI: Inferred from physical interaction
27749823 MGI
located in nucleolus IDA
IDA: Inferred from direct assay
9701556 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

RNA polymerase-associated protein RTF1 homolog

  • Rtf1, Paf1/RNA polymerase II complex component, homolog

  • gene trap locus 7

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12318 RTF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22315 Rtf1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28837 Rtf1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rtf1 NCBI NCBI:23168