Bhlhe41 - basic helix-loop-helix family, member e41 Gene

Also Known as DEC2; Bhlhb3; Sharp1; Bhlhb2l; 6430520M22Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 79362

Summary

This gene encodes a basic helix-loop-helix protein expressed in various tissues. The encoded protein can interact with Arntl or compete for E-box binding sites in the promoter of Per1 and repress Clock/Arntl's transactivation of Per1. This gene is believed to be involved in the control of circadian rhythm and cell differentiation. Defects in this gene are associated with the short sleep phenotype. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2014]

Bhlhe41 Products (2)

mRNA	Protein	Name
NM_001271768.1	NP_001258697.1	class E basic helix-loop-helix protein 41 isoform 2
NM_024469.2	NP_077789.1	class E basic helix-loop-helix protein 41 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	12397359	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	12397359	MGI
enables E-box binding	IDA IDA: Inferred from direct assay	12397359	MGI
enables MRF binding	IDA IDA: Inferred from direct assay	12657651	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	12657651	MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding	IDA IDA: Inferred from direct assay	17487425	MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	12657651	MGI
enables bHLH transcription factor binding	IDA IDA: Inferred from direct assay	12657651	MGI
enables bHLH transcription factor binding	IPI IPI: Inferred from physical interaction	12397359	MGI
enables histone deacetylase binding	IDA IDA: Inferred from direct assay	17487425	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12397359	MGI
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	12397359	MGI
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	17487425	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in circadian regulation of gene expression	IMP IMP: Inferred from mutant phenotype	18411297	MGI
involved in circadian rhythm	IEP IEP: Inferred from expression pattern	19786558	MGI
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12397359	MGI
involved in negative regulation of myotube differentiation	IDA IDA: Inferred from direct assay	12657651	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12397359	MGI
involved in negative regulation of transcription by competitive promoter binding	IDA IDA: Inferred from direct assay	12657651	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
class E basic helix-loop-helix protein 41	bHLH transcriptional factor Dec2 basic helix-loop-helix domain containing, class B3 class B basic helix-loop-helix protein 3 differentially expressed in chondrocytes protein 2

Bhlhe41 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Bhlhe41	Q99PV5	Cebpb	Mus musculus	P28033	Pull Down	19029947
Intra	Bhlhe41	Q99PV5	Cebpb	Mus musculus	P28033	Anti Tag CoIP	19029947
Cross	Bhlhe41	Q99PV5	PSMA4	Homo sapiens	P25789	Anti Tag CoIP	22801492
Cross	Bhlhe41	Q99PV5	HIF1A	Homo sapiens	Q16665	Anti Tag CoIP	22801492

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01494	BHLHE41 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Bhlhe41	NCBI	NCBI:79365