CIR1 - corepressor interacting with RBPJ, CIR1 Gene

Also Known as CIR

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9541

About CIR1

Cytogenetic location: 2q31.1 Genomic coordinates (GRCh38): 2:174,348,022-174,395,712 (from NCBI)

This gene has 5 transcripts (splice variants) and 197 orthologues. Ubiquitous expression in bone marrow (RPKM 20.7), testis (RPKM 18.7) and 25 other tissues.

Summary

Enables histone deacetylase binding activity; protein kinase binding activity; and transcription corepressor activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nuclear speck. Part of protein-containing complex. Colocalizes with centrosome. [provided by Alliance of Genome Resources, Apr 2022]

CIR1 Products (1)

mRNA Protein Name
NM_004882.4 NP_004873.3 corepressor interacting with RBPJ 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables histone deacetylase binding IDA
IDA: Inferred from direct assay
9874765 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9874765 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
20873783 GOA
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
9874765 GOA
enables transcription corepressor activity IDA
IDA: Inferred from direct assay
9874765 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
9874765 GOA
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
9874765 GOA
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9874765 GOA
Cellular Component GO Annotation Evidence References Source
colocalizes with centrosome IDA
IDA: Inferred from direct assay
20873783 GOA
located in nuclear speck IDA
IDA: Inferred from direct assay
15652350 GOA
located in nucleus IDA
IDA: Inferred from direct assay
9874765 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
20873783 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CIR1 Protein Structure

Cir_N

Cir_N: N-terminal domain of CBF1 interacting co-repressor CIR (13 - 49)

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  • 450 a.a.
Protein Preferred Names Protein Names

corepressor interacting with RBPJ 1

  • CBF1 (RBPJ) interacting corepressor 1

CIR1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CIR1 Q86X95 SRSF2 Homo sapiens Q01130
Anti Tag CoIP
15652350
Intra
CIR1 Q86X95 SRSF2 Homo sapiens Q01130
Y2H
15652350
Intra
CIR1 Q86X95 U2AF1 Homo sapiens Q01081
Y2H
15652350
Intra
CIR1 Q86X95 U2AF1 Homo sapiens Q01081
Pull Down
15652350
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Neurodermatitis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02720 CIR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15364 UBE2V1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20706 Cir1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27217 Cir1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CIR1 RGD RGD:1309199
Felis catus CIR1 VGNC VGNC:60907
Macaca mulatta CIR1 VGNC VGNC:71331
Mus musculus CIR1 MGD MGI:1914185
Bos taurus CIR1 VGNC VGNC:59328
Others CIR1 NCBI