TTI1 - TELO2 interacting protein 1 Gene

Also Known as smg-10; KIAA0406

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9675

About TTI1

Cytogenetic location: 20q11.23 Genomic coordinates (GRCh38): 20:37,983,021-38,033,456 (from NCBI)

This gene has 6 transcripts (splice variants) and 201 orthologues. Ubiquitous expression in testis (RPKM 7.8), thyroid (RPKM 6.4) and 25 other tissues.

Summary

Involved in regulation of TOR signaling. Located in cytoplasm. Part of TORC1 complex and TORC2 complex. [provided by Alliance of Genome Resources, Apr 2022]

TTI1 Products (2)

mRNA Protein Name
NM_001303457.2 NP_001290386.1 TELO2-interacting protein 1 homolog
NM_014657.3 NP_055472.1 TELO2-interacting protein 1 homolog

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20371770 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of DNA damage checkpoint IMP
IMP: Inferred from mutant phenotype
36724785 GOA
involved in regulation of TOR signaling IMP
IMP: Inferred from mutant phenotype
23263282 GOA
Cellular Component GO Annotation Evidence References Source
part of TORC1 complex IDA
IDA: Inferred from direct assay
23263282 GOA
part of TORC1 complex IMP
IMP: Inferred from mutant phenotype
36724785 GOA
part of TORC2 complex IDA
IDA: Inferred from direct assay
23263282 GOA
part of TORC2 complex IMP
IMP: Inferred from mutant phenotype
36724785 GOA
part of TTT Hsp90 cochaperone complex IPI
IPI: Inferred from physical interaction
20810650 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
23263282 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

TELO2-interacting protein 1 homolog

  • TEL2-interacting protein 1 homolog

TTI1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TTI1 O43156 TELO2 Homo sapiens Q9Y4R8
Anti Tag CoIP
20810650
Intra
TTI1 O43156 TELO2 Homo sapiens Q9Y4R8
Pull Down
20371770
Intra
TTI1 O43156 ATM Homo sapiens Q13315
Anti Bait CoIP
20810650
Intra
TTI1 O43156 ATM Homo sapiens Q13315
Anti Tag CoIP
20810650
Intra
TTI1 O43156 ATR Homo sapiens Q13535
Anti Tag CoIP
20810650
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15224 TTI1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-106991 Amustaline Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TTI1 VGNC VGNC:47969
Macaca mulatta TTI1 VGNC VGNC:79770
Felis catus TTI1 VGNC VGNC:66681
Rattus norvegicus TTI1 RGD RGD:1562582
Bos taurus TTI1 VGNC VGNC:36485
Mus musculus TTI1 MGD MGI:1922675
Others TTI1 NCBI