IL31RA
Interleukin-31 receptor alpha (IL-31RA, also called GPL or GLM-R) is the private ligand-binding subunit of the functional IL-31 receptor, pairing with oncostatin M receptor beta (OSMRβ) to form the heterodimeric complex for the pruritogenic cytokine IL-31. IL-31RA is a class I cytokine receptor with an N-terminal Ig-like domain, a cytokine-binding homology region including the WSXWS motif, and a cytoplasmic tail containing box 1 and STAT-docking tyrosines that recruit JAK1 and activate STAT3/STAT5, ERK1/2 and PI3K. Notably, IL-31RA is expressed by sensory neurons of dorsal root ganglia, keratinocytes, epithelial cells and eosinophils, but not resting lymphocytes, conferring tissue-specific responsiveness focused on skin and mucosa. IL-31RA expression is upregulated in atopic dermatitis lesions. Engagement of the receptor mediates neuroimmune communication, inducing pruritus, epidermal acanthosis and barrier disruption; genetic IL31RA variants are linked to eczema herpeticum susceptibility.
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IL31RA Recombinant Proteins (5)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
