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Cat. No.: HY-158410

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PSA-IN-1

PSA-IN-1 (compound 19) is a puromycin sensitive aminopeptidase (PSA) inhibitor with IC₅₀ at 7 nM. PSA-IN-1 has analgesic activity.

For research use only. We do not sell to patients.

Formula: C₂₈H₃₂ClN₇O₃S
Molecular Weight:582.12

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

PSA-IN-1 Chemical Structure

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Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vivo
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

PSA-IN-1 (compound 19) is a puromycin sensitive aminopeptidase (PSA) inhibitor with IC₅₀ at 7 nM. PSA-IN-1 has analgesic activity^[1].

All Aminopeptidase Isoforms :

CD13
LTA4H

Cellular Effect

Cell Line	Type	Value	Description	References
Vero	CC₅₀	>100 μM Compound: 19	Cytotoxicity against African green monkey Vero cells by MTT assay Cytotoxicity against African green monkey Vero cells by MTT assay	[PMID: 38917665]

In Vivo

PSA-IN-1 (50 or 100 μg/mouse, intraventricular administration) alone or combined with MET-enkephalin significantly reduces pain response in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 582.12
Formula C₂₈H₃₂ClN₇O₃S
SMILES

O[C@@H]1[C@H](NC([C@H](CSC(C2=CC=CC=C2)C3=CC=CC=C3)N)=O)[C@@H](CCl)O[C@H]1N4C=NC5=C(N=CN=C54)N(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Singh R, et al. Modulation of endogenous opioid signaling by inhibitors of puromycin sensitive aminopeptidase. bioRxiv [Preprint]. 2024 Apr 3:2024.04.02.587756. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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