2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. DMP-543

DMP-543 (XR-543) is a KV7 channel blocker, also acts as a potent neurotransmitter release enhancer.

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DMP-543

DMP-543 構造式

CAS 番号 : 160588-45-4

容量 価格（税別） 在庫状況 数量
>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 66 在庫あり
Solution
10 mM * 1 mL in DMSO USD 66 在庫あり
Solid
5 mg $60 在庫あり
10 mg $100 在庫あり
25 mg $200 在庫あり
50 mg $320 在庫あり
100 mg $520 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Other Forms of DMP-543:

DMP-543 関連抗体

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  • 純度とドキュメンテーション

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製品説明

DMP-543 (XR-543) is a KV7 channel blocker, also acts as a potent neurotransmitter release enhancer[1][2].

IC50 & Target

KV7 channel
Cellular Effect
Cell Line Type Value Description References
HEK293 CC50
77 μM
Compound: 3; DMP-543
Cytotoxicity against human HEK293 cells assessed as reduction in cell viability incubated for 18 hrs by celltiter-glo assay
Cytotoxicity against human HEK293 cells assessed as reduction in cell viability incubated for 18 hrs by celltiter-glo assay
[PMID: 31668424]
HEK293 IC50
0.048 μM
Compound: 3; DMP-543
Inhibition of Kv7.2 in human HEK293 cells incubated for 1 hr by thallium flux assay
Inhibition of Kv7.2 in human HEK293 cells incubated for 1 hr by thallium flux assay
[PMID: 31668424]
HEK293 IC50
32 μM
Compound: 3; DMP-543
Inhibition of ERG in human HEK293 cells incubated for 1 hr by thallium flux assay
Inhibition of ERG in human HEK293 cells incubated for 1 hr by thallium flux assay
[PMID: 31668424]
HepG2 CC50
132 μM
Compound: 3; DMP-543
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 18 hrs by celltiter-glo assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 18 hrs by celltiter-glo assay
[PMID: 31668424]
体外実験

DMP-543 enhances [3H]ACh release from rat brain slices, with an EC50 of 700 nM[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DMP-543 関連抗体
分子量

412.43

分子式

C26H18F2N2O
CAS 番号
Appearance

Solid

Color

White to yellow

SMILES

O=C1C2=C(C=CC=C2)C(CC3=CC(F)=NC=C3)(CC4=CC(F)=NC=C4)C5=CC=CC=C15
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 100 mg/mL (242.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4247 mL 12.1233 mL 24.2465 mL
5 mM 0.4849 mL 2.4247 mL 4.8493 mL
10 mM 0.2425 mL 1.2123 mL 2.4247 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: 2.5 mg/mL (6.06 mM); Suspended solution; Need ultrasonic

    This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: 2.5 mg/mL (6.06 mM); Suspended solution; Need ultrasonic

    This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション

純度: 99.96%

COA (259 KB) LCMS (93 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4247 mL 12.1233 mL 24.2465 mL 60.6163 mL
5 mM 0.4849 mL 2.4247 mL 4.8493 mL 12.1233 mL
10 mM 0.2425 mL 1.2123 mL 2.4247 mL 6.0616 mL
15 mM 0.1616 mL 0.8082 mL 1.6164 mL 4.0411 mL
20 mM 0.1212 mL 0.6062 mL 1.2123 mL 3.0308 mL
25 mM 0.0970 mL 0.4849 mL 0.9699 mL 2.4247 mL
30 mM 0.0808 mL 0.4041 mL 0.8082 mL 2.0205 mL
40 mM 0.0606 mL 0.3031 mL 0.6062 mL 1.5154 mL
50 mM 0.0485 mL 0.2425 mL 0.4849 mL 1.2123 mL
60 mM 0.0404 mL 0.2021 mL 0.4041 mL 1.0103 mL
80 mM 0.0303 mL 0.1515 mL 0.3031 mL 0.7577 mL
100 mM 0.0242 mL 0.1212 mL 0.2425 mL 0.6062 mL
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DMP-543 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DMP-543160588-45-4XR-543DMP543DMP 543XR543XR 543Potassium ChannelKcsAInhibitorinhibitorinhibit

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製品名:
DMP-543
製品番号:
HY-108590
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