DOPE-PEG2000-CRPPR

DOPE-PEG2000-CRPPR: surface functionalization of liposomes and nanoparticles for heart-targeted drug delivery, applicable in cardiovascular disease therapy, myocardial ischemia treatment, and cardiac imaging.
Structural composition:
(1) DOPE; a fusogenic phospholipid with two oleoyl chains that anchors into lipid bilayers and promotes pH-responsive membrane fusion for intracellular cargo release;
(2) PEG2000; a hydrophilic polymer that provides steric stabilization, reduces opsonization and immune clearance, and extends circulation half-life;
(3) CRPPR peptide; a cardiac-homing peptide identified by in vivo phage display that specifically binds to receptors on cardiomyocytes and cardiac vasculature, directing nanocarriers to heart tissue for targeted delivery of cardioprotective drugs, anti-ischemic agents, or imaging contrast agents, significantly improving cardiac drug bioavailability while reducing systemic side effects.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.