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Cat. No.: HY-187415A

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DOPE-PEG2000-TAASGVRSMH

(Synonyms: DOPE-PEG2000-Mal-Cys-TAASGVRSMH)

DOPE-PEG2000-TAASGVRSMH is an amphiphilic lipid-PEG-peptide conjugate composed of 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) , polyethylene glycol 2000 (PEG2000) , and the TAASGVRSMH peptide.
DOPE provides a hydrophobic phospholipid anchor for membrane insertion, PEG2000 forms a hydrophilic spacer that enhances circulation stability, and the TAASGVRSMH peptide serves as a tumor-vasculature-homing ligand identified by in vivo phage display.
This conjugate can be used to functionalize liposomes and lipid nanoparticles for targeted drug delivery to tumor vasculature.

For research use only. We do not sell to patients.

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

DOPE-PEG2000-TAASGVRSMH Chemical Structure

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Biological Activity

Description

In Vitro

DOPE-PEG2000-TAASGVRSMH is used for surface modification of liposomes and lipid nanoparticles to achieve tumor vascular targeted drug delivery and molecular imaging.
Structural composition:
(1) DOPE: a phospholipid with two oleoyl chains that inserts into lipid bilayers, acting as a hydrophobic membrane anchor and providing pH-responsive fusogenic activity;
(2) PEG2000: a hydrophilic polymer chain that creates a steric barrier reducing opsonization and reticuloendothelial system (RES) clearance, thereby prolonging blood circulation half-life;
(3) TAASGVRSMH peptide: a tumor-homing peptide identified through in vivo phage display that specifically binds to tumor blood vessel endothelial cells, enabling active targeting of tumor vasculature for enhanced drug accumulation at tumor sites.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

SMILES

[DOPE-PEG2000-TAASGVRSMH]
Synonyms

DOPE-PEG2000-Mal-Cys-TAASGVRSMH
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.