[DPen2, Pen5] Enkephalin
[DPen2, Pen5] Enkephalin is a δ-opioid receptor selective analog of [Leu5]-Enkephalin (HY-P0288).
For research use only. We do not sell to patients.
- CAS No.: 88373-72-2
- Formula: C30H39N5O7S2
- Molecular Weight:645.79
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
![[DPen2, Pen5] Enkephalin Chemical Structure](https://file.medchemexpress.com/product_pic/hy-p3546.gif "Click to View [DPen2, Pen5] Enkephalin Chemical Structure")
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Opioid Receptor Isoforms
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Biological Activity
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δ Opioid Receptor/DOR |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Sprague-Dawley rats (260-280 g)[1]
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Dosage:0, 1.16, 11.6 μg/kg
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Administration:IP, administered on day 2 prior to presentation of eight training trials, on subsequent one-way avoidance responding.
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Result:Produced a significant impairment of avoidance performance at 1.16 ug/kg, while the 11.6 ug/kg dose was without significant effect.
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Animal Model:Male Sprague-Dawley rats (260-280 g)[1]
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Dosage:0, 0.332, 3.32 μg/kg
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Administration:IP, administered on day 1 immediately after presentation of two escape-only trials, on subsequent day 2 one-way avoidance responding in the second experiment
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Result:Produced a significant enhancement of avoidance performance at 0.332 ug/kg, while the 3.32 ug/kg dose was without significant effect.
Chemical Information
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CAS No. 88373-72-2
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Molecular Weight 645.79
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Formula C30H39N5O7S2
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Sequence Shortening
Y-{d-Pen}-GF-{Pen} (Disulfide bridge: d-Pen2-Pen5)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
H2O
Peptide Solubility and Storage Guidelines:
1. Calculate the length of the peptide.
2. Calculate the overall charge of the entire peptide according to the following table:
| Contents | Assign value | |
|---|---|---|
| Acidic amino acid | Asp (D), Glu (E), and the C-terminal -COOH. | -1 |
| Basic amino acid | Arg (R), Lys (K), His (H), and the N-terminal -NH2 | +1 |
| Neutral amino acid | Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) | 0 |
3. Recommended solution:
| Overall charge of peptide | Details |
|---|---|
| Negative (<0) |
1. Try to dissolve the peptide in water first. 2. If water fails, add NH4OH (<50 μL). 3. If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide. |
| Positive (>0) |
1. Try to dissolve the peptide in water first. 2. If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3. If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO. |
| Zero (=0) |
1. Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2. For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration. |
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
[DPen2, Pen5] Enkephalin Related Classifications
HY-P3546 Related Classifications
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