DPPE-PEG2000-LyP-1

DPPE-PEG2000-LyP-1 is specifically designed for active targeting nanomedicine applications. It can be incorporated into liposomes, lipid nanoparticles (LNPs), or other nanocarriers to confer ligand-directed targeting capability against p32/gC1qR protein on the surface of lymphatic vessels, tumor-associated macrophages, and tumor cells.
Composition and role of each component:
1. DPPE (dipalmitoylphosphatidylethanolamine): Lipid anchoring group-inserts into the lipid bilayer of liposomes/LNPs, providing stable membrane anchorage; its saturated C16 chains confer bilayer rigidity.
2. PEG (polyethylene glycol): Hydrophilic polymer spacer arm that forms a steric corona around nanoparticles, reducing opsonization and reticuloendothelial system (RES) clearance, prolonging circulation half-life, and providing spatial separation between the lipid surface and targeting ligand.
3. LyP-1 (LyP-1 peptide (CGNKRTRGC)): Targeting ligand-a cyclic 9-amino acid peptide that specifically binds to p32/gC1qR protein, which is highly expressed on tumor-associated macrophages, lymphatic endothelial cells, and certain tumor cells.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.