DPPE-PEG2000-THRPPMWSPVWP

DPPE-PEG2000-THRPPMWSPVWP is composed of three covalently linked components: 1. DPPE (1,2-dipalmitoyl-sn-glycerol-3-phosphoethanolamine): Lipid anchoring group-inserts into the lipid bilayer of the liposome/LNP, providing stable membrane anchoring; its saturated C16 chain imparts bilayer rigidity. 2. PEG 2000 (polyethylene glycol, molecular weight 2000): Hydrophilic polymer spacer arm-forms a steric hindrance crown around the nanoparticle, reducing opsonin activity and reticuloendothelial system (RES) clearance, prolonging circulating half-life, and providing steric separation between the lipid surface and the targeting ligand. 3. THRPPMWSPVWP peptide: Targeting/functional ligand-the THRPPMWSPVWP peptide specifically binds to the transferrin receptor (TfR), is subsequently endocytosed into TfR-expressing cells, and can mediate the nanocarrier's crossing of the blood-brain barrier (BBB).

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.