2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. (E)-GABAB receptor antagonist 1

(E)-GABAB receptor antagonist 1 

Cat. No.: HY-129636 Purity: 95.26%
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(E)-GABAB receptor antagonist 1 is a trans-GABAB receptor antagonist 1. GABAB receptor antagonist 1 (compound 14) is a selective and negative allosteric modulator of GABAB (γ-Aminobutyric acid) receptors. (E)-GABAB receptor antagonist 1 decreases GABA-induced IP3 (inositol trisphosphate) production with IC50 of 37.9 μM.

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(E)-GABAB receptor antagonist 1 Chemical Structure

(E)-GABAB receptor antagonist 1 Chemical Structure

CAS No. : 1611483-29-4

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Based on 1 publication(s) in Google Scholar

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(E)-GABAB receptor antagonist 1 Related Antibodies

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Description

(E)-GABAB receptor antagonist 1 is a trans-GABAB receptor antagonist 1. GABAB receptor antagonist 1 (compound 14) is a selective and negative allosteric modulator of GABAB (γ-Aminobutyric acid) receptors. (E)-GABAB receptor antagonist 1 decreases GABA-induced IP3 (inositol trisphosphate) production with IC50 of 37.9 μM[1].

IC50 & Target

GABAB receptor[1]
In Vitro

(E)-GABAB receptor antagonist 1 (compound 14) decreases agonist GABA-induced maximal effect of IP3 production in HEK293 cells overexpressing GABAB receptors and Gqi9 proteins without changing the EC50[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(E)-GABAB receptor antagonist 1 Related Antibodies
Molecular Weight

304.39

Formula

C18H24O4
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(O)C(/C=C/C1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1)=O.[(E)]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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(E)-GABAB receptor antagonist 1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(E)-GABAB receptor antagonist 11611483-29-4GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorInhibitorinhibitorinhibit

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