1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. GABA Receptor
  3. (E)-GABAB receptor antagonist 1

(E)-GABAB receptor antagonist 1 

Cat. No.: HY-129636
Handling Instructions

(E)-GABAB receptor antagonist 1 is a trans-GABAB receptor antagonist 1. GABAB receptor antagonist 1 (compound 14) is a selective and negative allosteric modulator of GABAB (γ-Aminobutyric acid) receptors. (E)-GABAB receptor antagonist 1 decreases GABA-induced IP3 (inositol trisphosphate) production with IC50 of 37.9 μM.

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(E)-GABAB receptor antagonist 1 Chemical Structure

(E)-GABAB receptor antagonist 1 Chemical Structure

CAS No. : 1611483-29-4

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Description

(E)-GABAB receptor antagonist 1 is a trans-GABAB receptor antagonist 1. GABAB receptor antagonist 1 (compound 14) is a selective and negative allosteric modulator of GABAB (γ-Aminobutyric acid) receptors. (E)-GABAB receptor antagonist 1 decreases GABA-induced IP3 (inositol trisphosphate) production with IC50 of 37.9 μM[1].

IC50 & Target

GABAB receptor[1]

In Vitro

(E)-GABAB receptor antagonist 1 (compound 14) decreases agonist GABA-induced maximal effect of IP3 production in HEK293 cells overexpressing GABAB receptors and Gqi9 proteins without changing the EC50[1].

Molecular Weight

304.38

Formula

C₁₈H₂₄O₄

CAS No.

1611483-29-4

SMILES

O=C(O)C(/C=C/C1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1)=O.[(E)]

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(E)-GABAB receptor antagonist 1
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