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Cat. No.: HY-10339A

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(E)-KW-2449

(E)-KW-2449 is a subtype-selective type II kinase inhibitor.

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CAS No.: 841258-76-2
Formule: C₂₀H₂₀N₄O
Masse moléculaire:332.41

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Please store the product under the recommended conditions in the Certificate of Analysis.

(E)-KW-2449 Chemical Structure

CAS No.: 841258-76-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
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Activité biologique

Description

(E)-KW-2449 is a subtype-selective type II kinase inhibitor^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
K562	GI₅₀	0.27 μM Compound: KW-2449	Antiproliferative activity against imatinib resistant human K562 cells harbouring wild type ABL assessed as cell growth inhibition by XTT assay Antiproliferative activity against imatinib resistant human K562 cells harbouring wild type ABL assessed as cell growth inhibition by XTT assay	[PMID: 35551036]
MOLM-14	IC₅₀	14.8 nM Compound: 5, KW-2449	Inhibition of FLT3-mediated STAT5 phosphorylation in human MOLM14 cells Inhibition of FLT3-mediated STAT5 phosphorylation in human MOLM14 cells	10.1039/C1MD00175B
MV4-11	IC₅₀	45.7 nM Compound: KW-2449	Antiproliferative activity against human MV4-11 cells harboring FLT3-ITD mutant assessed as inhibition of cell growth incubated for 3 days by MTT assay Antiproliferative activity against human MV4-11 cells harboring FLT3-ITD mutant assessed as inhibition of cell growth incubated for 3 days by MTT assay	[PMID: 40387346]
MV4-11	IC₅₀	4.3 μM Compound: KW-2449	Antiproliferative activity against AC220R human MV4-11 cells assessed as inhibition of cell growth incubated for 3 days by MTT assay Antiproliferative activity against AC220R human MV4-11 cells assessed as inhibition of cell growth incubated for 3 days by MTT assay	[PMID: 40387346]

Chemical Information

CAS No. 841258-76-2
Masse moléculaire 332.41
Formule C₂₀H₂₀N₄O
SMILES

C(=C/C1=CC=C(C(=O)N2CCNCC2)C=C1)\C=3C=4C(NN3)=CC=CC4
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Davis MI, et al. Comprehensive analysis of kinase inhibitor selectivity. Nature biotechnology. 2011 Oct 30;29(11):1046-51. [Content Brief]

Calculators

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Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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