(E)-β-Ionone
Based on 1 Customer Validation
(E)-β-Ionone is the isomer of β-Ionone (HY-W015084). β-Ionone is effective in the induction of apoptosis in gastric adenocarcinoma SGC7901 cells. β-Ionone has anti-cancer activity.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 99.16%
- CAS No.: 79-77-6
- Formule: C13H20O
- Masse moléculaire:192.30
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Stockage:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| DU-145 | IC50 |
210 μM
Compound: 1
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Antiproliferative activity against human DU145 cells after 72 hrs by flow cytometry
Antiproliferative activity against human DU145 cells after 72 hrs by flow cytometry
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[PMID: 27474930] |
| LNCaP | IC50 |
130 μM
Compound: 1
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Antiproliferative activity against human LNCAP cells after 72 hrs by flow cytometry
Antiproliferative activity against human LNCAP cells after 72 hrs by flow cytometry
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[PMID: 27474930] |
| LNCaP | IC50 |
151 μM
Compound: Beta-ionone
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Cytotoxicity against human LNCAP cells after 72 hrs by MTT assay
Cytotoxicity against human LNCAP cells after 72 hrs by MTT assay
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[PMID: 19725582] |
| MCF7 | IC50 |
104 μM
Compound: 1
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Antiproliferative activity against human MCF7 cells
Antiproliferative activity against human MCF7 cells
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[PMID: 27474930] |
| MDA-MB-435 | IC50 |
42 μM
Compound: 1
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Growth inhibition of human MDA-MB-435 cells after 7 days relative to control
Growth inhibition of human MDA-MB-435 cells after 7 days relative to control
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[PMID: 27474930] |
| PC-3 | IC50 |
130 μM
Compound: 1
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Antiproliferative activity against human PC3 cells after 72 hrs by flow cytometry
Antiproliferative activity against human PC3 cells after 72 hrs by flow cytometry
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[PMID: 27474930] |
| SGC-7901 | IC50 |
174.93 μM
Compound: 1
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Antiproliferative activity against human SGC7901 cells
Antiproliferative activity against human SGC7901 cells
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[PMID: 27474930] |
| SGC-7901 | IC50 |
89 μM
Compound: 1
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Growth inhibition of human SGC7901 cells after 24 to 48 hrs by MTT assay
Growth inhibition of human SGC7901 cells after 24 to 48 hrs by MTT assay
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[PMID: 27474930] |
Chemical Information
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CAS No. 79-77-6
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Appearance Liquid (Density: 0.9385 g/cm3)
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Masse moléculaire 192.30
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Formule C13H20O
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Color Colorless to light yellow
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SMILES
CC(/C=C/C1=C(C)CCCC1(C)C)=O
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Synonyms
β-Lonone
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Solvant et solubilité
DMSO : 100 mg/mL (520.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (13.00 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (13.00 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureté et documentation
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Fiche technique (271 KB)
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SDS (398 KB)
- English - EN (398 KB)
- Français - FR (398 KB)
- Deutsch - DE (398 KB)
- Norwegian - NO (398 KB)
- Español - ES (398 KB)
- Swedish - SV (398 KB)
- Italian - IT (398 KB)
- Korean - KR (398 KB)
- Portuguese - PT (398 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.2002 mL | 26.0010 mL | 52.0021 mL | 130.0052 mL |
| 5 mM | 1.0400 mL | 5.2002 mL | 10.4004 mL | 26.0010 mL | |
| 10 mM | 0.5200 mL | 2.6001 mL | 5.2002 mL | 13.0005 mL | |
| 15 mM | 0.3467 mL | 1.7334 mL | 3.4668 mL | 8.6670 mL | |
| 20 mM | 0.2600 mL | 1.3001 mL | 2.6001 mL | 6.5003 mL | |
| 25 mM | 0.2080 mL | 1.0400 mL | 2.0801 mL | 5.2002 mL | |
| 30 mM | 0.1733 mL | 0.8667 mL | 1.7334 mL | 4.3335 mL | |
| 40 mM | 0.1300 mL | 0.6500 mL | 1.3001 mL | 3.2501 mL | |
| 50 mM | 0.1040 mL | 0.5200 mL | 1.0400 mL | 2.6001 mL | |
| 60 mM | 0.0867 mL | 0.4334 mL | 0.8667 mL | 2.1668 mL | |
| 80 mM | 0.0650 mL | 0.3250 mL | 0.6500 mL | 1.6251 mL | |
| 100 mM | 0.0520 mL | 0.2600 mL | 0.5200 mL | 1.3001 mL |
(E)-β-Ionone Related Classifications
HY-W015084A Related Classifications
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