E3 ligase Ligand 14

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E3 ligase Ligand 14 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 14 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins.

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E3 ligase Ligand 14 Chemical Structure

CAS No. : 2241489-43-8

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1 g		Get quote	Estimated Time of Arrival: December 31
2 g		Get quote	Estimated Time of Arrival: December 31

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Description	E3 ligase Ligand 14 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 14 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins^[1].
Molecular Weight	676.84
Formula	C₃₈H₅₂N₄O₇
CAS No.	2241489-43-8
SMILES	O=C(N[C@@H]1CCCC2=C1C=CC=C2)[C@H]3N(C[C@H](C3)OC4=CC=CC(O)=C4)C([C@@H](NC([C@H](C)N(C(OC(C)(C)C)=O)C)=O)C5CCCCC5)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (270 KB) Handling Instructions (2659 KB)
References	[1]. Shibata N, et al. Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands. J Med Chem. 2018 Jan 25;61(2):543-575. [Content Brief]

E3 ligase Ligand 14 Related Classifications

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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E3 ligase Ligand 142241489-43-8Ligands for E3 LigaseE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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E3 ligase Ligand 14

E3 ligase Ligand 14 Related Antibodies

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