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United States

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製品番号: HY-162623

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EGFR/HER2-IN-15

EGFR/HER2-IN-15, a dihydropyrimidine, is a potent EGFR/HER2 inhibitor. EGFR/HER2-IN-15 significantly inhibits EGFR^wt activity with an IC₅₀ of 37.21 nM. EGFR/HER2-IN-15 has anticaner effects.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₂₈H₂₉N₃O₆
分子量:503.55

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

EGFR/HER2-IN-15 構造式

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体外実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

^[1]

EGFR (WT)

37.21 nM (IC₅₀)

EGFR アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
MCF7	IC₅₀	9.38 μM Compound: 21	Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth measured after 3 days by MTT assay Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth measured after 3 days by MTT assay	[PMID: 38908102]
Vero	IC₅₀	18.35 μM Compound: 21	Cytotoxicity against African green monkey Vero cells assessed as inhibition of cell growth measured after 3 days by MTT assay Cytotoxicity against African green monkey Vero cells assessed as inhibition of cell growth measured after 3 days by MTT assay	[PMID: 38908102]

体外実験

At a concentration of 1000 nM EGFR/HER2-IN-15 (compound 21) shows 98.51% and 96.79% inhibition of EGFR and HER2 expression^[1].
EGFR/HER2-IN-15 inhibits MCF-7 breast cancer cells with an IC₅₀ of 9.38 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

分子量 503.55
分子式 C₂₈H₂₉N₃O₆
SMILES

O=C1NC(C)=C(C(NC2=CC=C(OC)C=C2OC)=O)C(C3=CC(OC)=C(OCC4=CC=CC=C4)C=C3)N1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (273 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Syed Faizanm, et al. Novel dihydropyrimidines as promising EGFR & HER2 inhibitors: Insights from experimental and computational studies. Eur J Med Chem. 2024 Jun 19:275:116607. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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