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Cat. No.: HY-162623

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EGFR/HER2-IN-15

EGFR/HER2-IN-15, a dihydropyrimidine, is a potent EGFR/HER2 inhibitor. EGFR/HER2-IN-15 significantly inhibits EGFR^wt activity with an IC₅₀ of 37.21 nM. EGFR/HER2-IN-15 has anticaner effects.

For research use only. We do not sell to patients.

Formula: C₂₈H₂₉N₃O₆
Molecular Weight:503.55

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

EGFR/HER2-IN-15 Chemical Structure

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Use of MCE Products

Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

EGFR (WT)

37.21 nM (IC₅₀)

All EGFR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
MCF7	IC₅₀	9.38 μM Compound: 21	Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth measured after 3 days by MTT assay Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth measured after 3 days by MTT assay	[PMID: 38908102]
Vero	IC₅₀	18.35 μM Compound: 21	Cytotoxicity against African green monkey Vero cells assessed as inhibition of cell growth measured after 3 days by MTT assay Cytotoxicity against African green monkey Vero cells assessed as inhibition of cell growth measured after 3 days by MTT assay	[PMID: 38908102]

In Vitro

At a concentration of 1000 nM EGFR/HER2-IN-15 (compound 21) shows 98.51% and 96.79% inhibition of EGFR and HER2 expression^[1].
EGFR/HER2-IN-15 inhibits MCF-7 breast cancer cells with an IC₅₀ of 9.38 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 503.55
Formula C₂₈H₂₉N₃O₆
SMILES

O=C1NC(C)=C(C(NC2=CC=C(OC)C=C2OC)=O)C(C3=CC(OC)=C(OCC4=CC=CC=C4)C=C3)N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Syed Faizanm, et al. Novel dihydropyrimidines as promising EGFR & HER2 inhibitors: Insights from experimental and computational studies. Eur J Med Chem. 2024 Jun 19:275:116607. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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EGFR/HER2-IN-15

All EGFR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

EGFR/HER2-IN-15 Related Classifications

HY-162623 Related Classifications