Enarodustat hydrochloride
Based on 4 publication(s) in Google Scholar
Enarodustat hydrochloride is a potent and orally active HIF/HIF Prolyl-Hydroxylase inhibitor, with an EC50 of 0.22 μM. Enarodustat hydrochloride has the potential for renal anemia treatment.
For research use only. We do not sell to patients.
- CAS No.: 1262131-60-1
- Formula: C17H17ClN4O4
- Molecular Weight:376.79
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) Enarodustat hydrochloride
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Biological Activity
Description
IC50 & Target
pKi : 8.2 (5-HT2A receptor), 8.0 (D4 receptor), 6.7 (D2 receptor), 7.2 (α1 receptor), 6.9 (5-HT2C receptor), 5.7 (H1 receptor)[1]
In Vitro
Enarodustat hydrochloride (JTZ-951) is a potent and orally active hypoxia-inducible factor prolyl hydroxylase inhibitor, with an EC50 of 0.22 μM. Enarodustat hydrochloride exhibits neither CYP (IC50 > 100 μM; CYP3A4/5, CYP2C9, CYP2D6, CYP1A2, CYP2A6, CYP2C19, CYP2C8, CYP2B6) nor hERG (IC50 > 100 μM) inhibition[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1262131-60-1
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Molecular Weight 376.79
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Formula C17H17ClN4O4
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SMILES
O=C(C(C1=NC=NN1C(CCC2=CC=CC=C2)=C3)=C3O)NCC(O)=O.Cl
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Synonyms
JTZ-951 hydrochloride; SAL0951 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (4)
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Journal Impact Factor
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Most Recent
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Life Sci
The drug-specific properties of hypoxia-inducible factor-prolyl hydroxylase inhibitors in mice reveal a significant contribution of the kidney compared to the liver to erythropoietin induction. [Abstract]2024 Jun 1:346:122641. PMID: 38614299 -
ACS Omega
UHPLC-HRMS Method for the Simultaneous Screening of 235 Drugs in Capillary Blood for Doping Control Purpose: Comparative Evaluation of Volumetric and Non-volumetric Dried Blood Spotting Devices. [Abstract]2022 Aug 29;7(36):31845-31868. PMID: 36119994 -
ChemMedChem
Crystallographic and Selectivity Studies on the Approved HIF Prolyl Hydroxylase Inhibitors Desidustat and Enarodustat. [Abstract]2024 Dec 16;19(24):e202400504. PMID: 39291299 -
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Enarodustat hydrochloride Related Classifications
HY-109057A Related Classifications
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