1. GPCR/G Protein
  2. Platelet-activating Factor Receptor (PAFR)
  3. Epiyangambin

Epiyangambin is a competitive platelet activating factor receptor (PAF) antagonist that dose-dependently inhibits PAF-induced platelet aggregation. Epiyangambin also inhibits the growth of human colon cancer cells (SW480 cells).

For research use only. We do not sell to patients.

Epiyangambin Chemical Structure

Epiyangambin Chemical Structure

CAS No. : 24192-64-1

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Description

Epiyangambin is a competitive platelet activating factor receptor (PAF) antagonist that dose-dependently inhibits PAF-induced platelet aggregation. Epiyangambin also inhibits the growth of human colon cancer cells (SW480 cells)[1][2].

In Vitro

Epiyangambin (0-25 µM; 24 h) inhibits growth of SW480 cells in a dose-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: SW480 cells
Concentration: 0-25 µM
Incubation Time: 24 h
Result: Caused reductions in cell number in a dose-dependent manner.
In Vivo

Epiyangambin (20 mg/kg) significantly inhibits PAF (platelet activating factor)-induced thrombocytopenia in rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

446.49

Formula

C24H30O8

CAS No.
SMILES

COC1=C(OC)C(OC)=CC([C@H]2OC[C@]3([H])[C@H](C4=CC(OC)=C(OC)C(OC)=C4)OC[C@@]32[H])=C1

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Epiyangambin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Epiyangambin
Cat. No.:
HY-121377
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