AD06
AD06 is a SARS-CoV-2 main protease (Mpro) inhibitor with an IC50 of 163.3 nM. AD06 undergoes nucleophilic attack by deprotonated Cys145, thereby blocking viral replication. AD06 inhibits the activity of wild-type SARS-CoV-2 and shows no significant cytotoxicity in mammalian cells. AD06 can be used in studies related to SARS-CoV-2 infection.
For research use only. We do not sell to patients.
- Formula: C22H32ClN5O5S
- Molecular Weight:514.04
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
AD06 exhibits moderate antiviral activity against SARS-CoV-2 in Vero E6 cells with an EC50 of 25.58 μM[1].
AD06 does not exhibit notable cytotoxicity in Vero E6 cells, with a CC50 > 100 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 514.04
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Formula C22H32ClN5O5S
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SMILES
CC(C[C@@H](C(N[C@@H](C[C@@H]1CCNC1=O)C=O)=O)NC([C@H](C(C)C)NC(C2=CSC(Cl)=N2)=O)=O)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AD06 Related Classifications
HY-184147 Related Classifications
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