ARPC4 - actin related protein 2/3 complex subunit 4 Gene

Also Known as ARC20; DEVLO; P20-ARC

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10093

About ARPC4

Cytogenetic location: 3p25.3 Genomic coordinates (GRCh38): 3:9,792,518-9,807,101 (from NCBI)

This gene has 8 transcripts (splice variants), 269 orthologues and is associated with 1 phenotype. Ubiquitous expression in lymph node (RPKM 63.0), appendix (RPKM 61.6) and 25 other tissues.

Summary

This gene encodes one of seven subunits of the human Arp2/3 protein complex. This complex controls actin polymerization in cells and has been conserved throughout eukaryotic evolution. This gene encodes the p20 subunit, which is necessary for actin nucleation and high-affinity binding to F-actin. Alternative splicing results in multiple transcript variants. Naturally occurring read-through transcription exists between this gene and the downstream tubulin tyrosine ligase-like family, member 3 (TTLL3), which results in the production of a fusion protein. [provided by RefSeq, Nov 2010]

ARPC4 Products (4)

mRNA	Protein	Name
NM_001024959.3	NP_001020130.1	actin-related protein 2月3日 complex subunit 4 isoform b
NM_001024960.3	NP_001020131.1	actin-related protein 2月3日 complex subunit 4 isoform b
NM_001198780.3	NP_001185709.1	actin-related protein 2月3日 complex subunit 4 isoform c
NM_005718.5	NP_005709.1	actin-related protein 2月3日 complex subunit 4 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
contributes to actin filament binding	IDA IDA: Inferred from direct assay	11741539	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	23921388	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11162547	GOA
contributes to protein-macromolecule adaptor activity	IPI IPI: Inferred from physical interaction	11162547	GOA
enables structural constituent of cytoskeleton	IDA IDA: Inferred from direct assay	11741539	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in Arp2/3 complex-mediated actin nucleation	IDA IDA: Inferred from direct assay	11741539	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of Arp2/3 protein complex	IDA IDA: Inferred from direct assay	11162547	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARPC4 Protein Structure

ARPC4

0
100
168 a.a.

Protein Preferred Names	Protein Names
actin-related protein 2/3 complex subunit 4	actin related protein 2/3 complex, subunit 4, 20kDa

ARPC4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ARPC4	P59998	PNMA5	Homo sapiens	Q96PV4	Validated Y2H	32296183
Intra	ARPC4	P59998	PNMA5	Homo sapiens	Q96PV4	Y2H Array	25416956
Intra	ARPC4	P59998	PNMA5	Homo sapiens	Q96PV4	Y2H Array	31515488
Intra	ARPC4	P59998	PNMA5	Homo sapiens	Q96PV4	Validated Y2H	25416956
Intra	ARPC4	P59998	ARPC3	Homo sapiens	O15145	TAP	24981860
Intra	ARPC4	P59998	ARPC5L	Homo sapiens	Q9BPX5	Validated Y2H	32296183
Intra	ARPC4	P59998	ARPC5L	Homo sapiens	Q9BPX5	Y2H Array	32296183
Intra	ARPC4	P59998	ARPC5L	Homo sapiens	Q9BPX5	Anti Tag CoIP	33961781
Intra	ARPC4	P59998	ARPC5L	Homo sapiens	Q9BPX5	Y2H Prey Pooling	32296183
Intra	ARPC4	P59998	ARPC5L	Homo sapiens	Q9BPX5	TAP	24981860
Intra	ARPC4	P59998	METTL21A	Homo sapiens	Q8WXB1	Validated Y2H	32296183
Intra	ARPC4	P59998	WASL	Homo sapiens	O00401	Y2H Array	32296183
Intra	ARPC4	P59998	WASL	Homo sapiens	O00401	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Patellar Tendinitis	Patellar Tendonitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01021	ARPC4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ARPC4	RGD	RGD:1310096
Felis catus	ARPC4	VGNC	VGNC:69349
Canis familiaris	ARPC4	VGNC	VGNC:54574
Mus musculus	ARPC4	MGD	MGI:1915339
Others	ARPC4	NCBI