IL6ST - interleukin 6 cytokine family signal transducer Gene

Also Known as CD130; GP130; HIES4; IMD94; STWS2; CDW130; HIES4A; HIES4B; IL-6RB; sGP130

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3572

About IL6ST

Cytogenetic location: 5q11.2 Genomic coordinates (GRCh38): 5:55,935,095-55,994,963 (from NCBI)

This gene has 25 transcripts (splice variants), 133 orthologues, 23 paralogues and is associated with 77 phenotypes. Ubiquitous expression in placenta (RPKM 88.6), fat (RPKM 53.5) and 24 other tissues.

Summary

The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), Leukemia Inhibitory Factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte Apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014]

IL6ST Products (8)

mRNA	Protein	Name
NM_001190981.2	NP_001177910.1	interleukin-6 receptor subunit beta isoform 3 precursor
NM_001364275.2	NP_001351204.1	interleukin-6 receptor subunit beta isoform 4 precursor
NM_001364276.2	NP_001351205.1	interleukin-6 receptor subunit beta isoform 5 precursor
NM_001364277.2	NP_001351206.1	interleukin-6 receptor subunit beta isoform 6
NM_001364278.2	NP_001351207.1	interleukin-6 receptor subunit beta isoform 7
NM_001364279.2	NP_001351208.1	interleukin-6 receptor subunit beta isoform 8
NM_002184.4	NP_002175.2	interleukin-6 receptor subunit beta isoform 1 precursor
NM_175767.3	NP_786943.1	interleukin-6 receptor subunit beta isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ciliary neurotrophic factor receptor activity	IDA IDA: Inferred from direct assay	12643274	GOA
enables ciliary neurotrophic factor receptor binding	IPI IPI: Inferred from physical interaction	12707266	GOA
enables coreceptor activity	IDA IDA: Inferred from direct assay	8637716	GOA
contributes to growth factor binding	IPI IPI: Inferred from physical interaction	8999038	GOA
enables growth factor binding	IPI IPI: Inferred from physical interaction	8999038	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	24501689	GOA
contributes to interleukin-6 binding	IPI IPI: Inferred from physical interaction	12829785	GOA
contributes to interleukin-6 receptor activity	IDA IDA: Inferred from direct assay	2261637	GOA
contributes to interleukin-6 receptor binding	IPI IPI: Inferred from physical interaction	12829785	GOA
contributes to leukemia inhibitory factor receptor activity	IDA IDA: Inferred from direct assay	8999038	GOA
contributes to oncostatin-M receptor activity	IDA IDA: Inferred from direct assay	8999038	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8662591	GOA
enables protein tyrosine kinase activator activity	IDA IDA: Inferred from direct assay	12829785	GOA
enables scaffold protein binding	IPI IPI: Inferred from physical interaction	31145836	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cell surface receptor signaling pathway via STAT	IMP IMP: Inferred from mutant phenotype	14764690	GOA
involved in ciliary neurotrophic factor-mediated signaling pathway	IDA IDA: Inferred from direct assay	12643274	GOA
involved in cytokine-mediated signaling pathway	IDA IDA: Inferred from direct assay	2261637	GOA
involved in interleukin-11-mediated signaling pathway	IDA IDA: Inferred from direct assay	8637716	GOA
involved in interleukin-27-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	14764690	GOA
involved in interleukin-6-mediated signaling pathway	IDA IDA: Inferred from direct assay	12829785	GOA
involved in interleukin-6-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	2261637	GOA
involved in intestinal epithelial cell development	IDA IDA: Inferred from direct assay	25731159	GOA
involved in leukemia inhibitory factor signaling pathway	IDA IDA: Inferred from direct assay	8999038	GOA
involved in negative regulation of interleukin-6-mediated signaling pathway	IDA IDA: Inferred from direct assay	8353278	GOA
involved in negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	19386761	GOA
involved in oncostatin-M-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	8999038	GOA
involved in positive regulation of Notch signaling pathway	IDA IDA: Inferred from direct assay	25731159	GOA
involved in positive regulation of T cell proliferation	IMP IMP: Inferred from mutant phenotype	14764690	GOA
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	2261637	GOA
involved in positive regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	8999038	GOA
involved in positive regulation of osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	12372336	GOA
involved in response to cytokine	IDA IDA: Inferred from direct assay	2261637	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of ciliary neurotrophic factor receptor complex	IDA IDA: Inferred from direct assay	12707266	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	8353278	GOA
part of interleukin-6 receptor complex	IDA IDA: Inferred from direct assay	2261637	GOA
is active in membrane raft	IDA IDA: Inferred from direct assay	31145836	GOA
part of oncostatin-M receptor complex	IDA IDA: Inferred from direct assay	8999038	GOA
is active in plasma membrane	IDA IDA: Inferred from direct assay	19915009	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IL6ST Protein Structure

Lep_receptor_Ig

IL6Ra-bind

fn3

0
200
400
600
800
918 a.a.

Protein Preferred Names	Protein Names
interleukin-6 receptor subunit beta	CD130 antigen

IL6ST Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	IL6ST	P40189	SGTB	Homo sapiens	Q96EQ0	Y2H Prey Pooling	32296183
Intra	IL6ST	P40189	SGTB	Homo sapiens	Q96EQ0	Validated Y2H	32296183
Intra	IL6ST	P40189	SGTB	Homo sapiens	Q96EQ0	Y2H Array	32296183
Intra	IL6ST	P40189	CNTF	Homo sapiens	P26441	Pull Down	16051226
Intra	IL6ST	P40189	SGTB	Homo sapiens	Q96EQ0	Y2H Array	29892012
Intra	IL6ST	P40189	IL6	Homo sapiens	P05231	SPR	8702737
Cross	IL6ST	P40189	Stat3	Mus musculus	P42227	Competition Binding	8662591
Intra	IL6ST	P40189	KCNIP1	Homo sapiens	Q9NZI2-2	Y2H Prey Pooling	32296183
Intra	IL6ST	P40189	KCNIP1	Homo sapiens	Q9NZI2-2	Validated Y2H	32296183
Intra	IL6ST	P40189	KCNIP1	Homo sapiens	Q9NZI2-2	Y2H Array	32296183
Intra	IL6ST	P40189	OSMR	Homo sapiens	Q99650	Anti Bait CoIP	24501689
Intra	IL6ST	P40189	SGTA	Homo sapiens	O43765	Y2H Prey Pooling	32296183
Intra	IL6ST	P40189	SGTA	Homo sapiens	O43765	Y2H Array	32296183
Intra	IL6ST	P40189	MAGEA11	Homo sapiens	P43364	Validated Y2H	32296183
Intra	IL6ST	P40189	MAGEA11	Homo sapiens	P43364	Y2H Array	32296183
Intra	IL6ST	P40189	MAGEA11	Homo sapiens	P43364	Y2H Prey Pooling	32296183
Intra	IL6ST	P40189	KCNIP3	Homo sapiens	Q9Y2W7	Y2H Array	32296183
Intra	IL6ST	P40189	KCNIP3	Homo sapiens	Q9Y2W7	MAPPIT	32296183
Intra	IL6ST	P40189	KCNIP3	Homo sapiens	Q9Y2W7	Y2H Prey Pooling	32296183
Intra	IL6ST	P40189	KCNIP3	Homo sapiens	Q9Y2W7	Validated Y2H	32296183
Cross	IL6ST	P40189	K2	Human herpesvirus 8	Q2HRC7	ELISA	11238858

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IL6ST Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75792	gp130/IL6ST Protein, Human (HEK293)	P40189-1/NP_002175.2 (E23-I618)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P75794	gp130/IL6ST Protein, Human (HEK293, Fc)	P40189-1 (E23-I618)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P75795	gp130/IL6ST Protein, Human (HEK293, His-Fc)	P40189-1 (E23-I618)	≥ 90%, as determined by reducing SDS-PAGE.

IL6ST Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84293	CD130 Antibody (YA3990)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Monkey
HY-P84293A	CD130 Antibody (YA3990)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Monkey

Related Diseases

Diseases	Alias
Hyper-Ige Recurrent Infection Syndrome 4b, Autosomal Recessive	Hyper-Ige Recurrent Infection Syndrome 4, Autosomal Recessive HIES4B HIES4
Immunodeficiency 94 With Autoinflammation And Dysmorphic Facies	IMD94
Hyper-Ige Recurrent Infection Syndrome 4a, Autosomal Dominant	HIES4A
Stuve-Wiedemann Syndrome 2	STWS2
Stuve-Wiedemann Syndrome 1	Stuve-Wiedemann Syndrome Sjs2 STWS Stuve-Wiedemann/Schwartz-Jampel Type 2 Syndrome Sws Schwartz-Jampel Syndrome Type 2 Stuve-Wiedemann Dysplasia Schwartz-Jampel Syndrome, Neonatal Stuve-Wiedemann Syndrome/Schwartz-Jampel Type 2 Syndrome Neonatal Schwartz-Jampel Syndrome Stüve-Wiedemann Syndrome 1 STWS1 Schwartz-Jampel Syndrome, Type 2 Neonatal Schwartz-Jampel Syndrome Type 2 Schwartz-Jampel Syndrome Neonatal Stüve-Wiedemann Syndrome Schwartz-Jampel Type 2 Syndrome
Hyper Ige Recurrent Infection Syndrome 4
Kaposi Sarcoma	Kaposi'S Sarcoma Kaposi Sarcoma, Susceptibility To Kaposi'S Sarcoma Of Lung Kaposi'S Sarcoma Of Palate Kaposi'S Sarcoma Of Soft Tissue Kaposi'S Sarcoma-Associated Herpesvirus Multiple Idiopathic Pigmented Hemangiosarcoma Multiple Idiopathic Pigmented Hemangiosarcoma, Susceptibility To African Lymphadenopathic Kaposi'S Sarcoma Anal Kaposi'S Sarcoma Cardiac Kaposi'S Sarcoma Central Nervous System Kaposi'S Sarcoma Conjunctival Kaposi'S Sarcoma Corneal Kaposi'S Sarcoma Cutaneous Kaposi'S Sarcoma Esophageal Kaposi'S Sarcoma Gallbladder Kaposi'S Sarcoma Gastric Kaposi'S Sarcoma Intestinal Kaposi'S Sarcoma Kaposi'S Sarcoma Of Anus Kaposi'S Sarcoma Of Central Nervous System Kaposi'S Sarcoma Of Conjunctiva Kaposi'S Sarcoma Of Cornea Kaposi'S Sarcoma Of Esophagus Kaposi'S Sarcoma Of Gastrointestinal Sites Kaposi'S Sarcoma Of Heart Kaposi'S Sarcoma Of Lymph Nodes Kaposi'S Sarcoma Of Penis Kaposi'S Sarcoma Of Skin Kaposi'S Sarcoma Of Soft Tissues Kaposi'S Sarcoma Of The Cns Kaposi'S Sarcoma Of The Gallbladder Kaposi'S Sarcoma Of The Prostate Kaposi'S Sarcoma, Lung Kaposi'S Sarcoma, Skin Lymph Node Kaposi'S Sarcoma Lymphadenopathic Kaposi'S Sarcoma Palate Kaposi'S Sarcoma Penis Kaposi'S Sarcoma Prostate Kaposi'S Sarcoma Pulmonary Kaposi'S Sarcoma Soft Tissue Kaposi'S Sarcoma Hhv8 Human Herpesvirus 8 Kshv Kaposi Sarcoma Herpesvirus Mediterranean Kaposi Sarcoma Non Aids Related Kaposi Sarcoma Sarcoma, Kaposi Sarcoma, Kaposi, Susceptibility To Non-Aids-Related Kaposi Sarcoma Angiolymphoid Hyperplasia Angiofollicular Ganglionic Hyperplasia Multi-Centric Castleman'S Disease
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Arthritis	Inflammatory Joint Disease Inflammatory Disorder Of Joint
Plasmacytoma	Solitary Plasmacytoma Solitary Myeloma Myeloma - Solitary Myeloma, Solitary Plasmacytoma - Category Solitary Osseous Plasmacytoma Solitary Plasmacytoma Without Mention Of Remission Localised Malignant Plasma Cell Tumour Nos Plasmacytoma Nos
Leukemia	Leukemias Leukaemia, Unspecified, Without Mention Of Remission Aleukemic Leukaemia Chronic Leukaemia Subacute Leukaemia Leukaemia Disorder Leukaemia Nos
Castleman Disease	Angiofollicular Ganglionic Hyperplasia Angiofollicular Lymph Hyperplasia Giant Lymph Node Hyperplasia Castleman'S Disease Angiofollicular Lymph Node Hyperplasia Lymphoid Hamartoma Benign Giant Lymphoma Angiolymphoid Hyperplasia
Craniosynostosis	Premature Closure Of Cranial Sutures Craniostenosis Craniosynostosis Syndrome Cso Craniosynostoses Congenital Ossification Of Cranial Sutures Congenital Ossification Of Sutures Of Skull Craniostosis Imperfect Fusion Of Skull Congenital Imperfect Closure Skull Imperfect Closure Skull Premature Closure Cranium Sutures Deficiency Of Craniofacial Axis
Liver Benign Neoplasm	Epithelial Hepatic And Intrahepatic Bile Duct Neoplasm
Sarcoma	Connective And Soft Tissue Neoplasm Tumor Of Soft Tissue And Skeleton Sarcomas Sarcoma - Category
Immunodeficiency 63 With Lymphoproliferation And Autoimmunity	IMD63 Il2rb Deficiency Cd122 Deficiency Immunodeficiency 63 Interleukin 2 Receptor, Beta, Deficiency Of Deficiency Of Interleukin 2 Receptor Beta
Myeloma, Multiple	Multiple Myeloma Plasma Cell Myeloma Kahler Disease Myelomatosis Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Kahler'S Disease Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]
Hepatocellular Adenoma	Adenoma Hepatocellular
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Scoliosis
Motor Neuron Disease	Anterior Horn Cell Disease Motor Neuron Diseases Mnd - [Motor Neurone Disease] Lou Gehrig Disease Creeping Palsy Creeping Paralysis Bulbar Motor Neuron Disease Bulbar Syndrome Anterior Horn Cell Disorder Hereditary Motor Neuron Disease
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Hyper Ige Syndrome	Hyper-Ige Syndrome Hyper Immunoglobulin E Syndrome Hies Hyper-Ige Recurrent Infection Syndrome Hyperimmunoglobulin E Syndrome Hyper Ige Job Syndrome Hartnup Disease
Hemochromatosis, Type 1	Hemochromatosis Hemochromatosis Type 1 Hereditary Hemochromatosis Hh HFE1 Hfe Hemochromatosis, Modifier Of Symptomatic Form Of Classic Hemochromatosis Symptomatic Form Of Hemochromatosis Type 1 Symptomatic Form Of Hfe-Related Hereditary Hemochromatosis Haemochromatosis Iron Storage Disorder Bronze Diabetes Hereditary Haemochromatosis Hlah Hfe Hemochromatosis, Hereditary Diabetes Bronze Classic Hemochromatosis Hfe-Associated Hereditary Hemochromatosis Hemochromatosis Classic Bronzed Cirrhosis Familial Hemochromatosis Genetic Hemochromatosis Hc Pigmentary Cirrhosis Primary Hemochromatosis Troisier-Hanot-Chauffard Syndrome Von Recklenhausen-Applebaum Disease Hemochromatosis 1 Primary Hereditary Hemochromatosis Bronze Cirrhosis
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Medulloblastoma Predisposition Syndrome Medulloblastoma, Somatic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Neuroectodermal Tumors, Primitive Medulloblastomas Desmoplastic Medulloblastoma Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Maturity-Onset Diabetes Of The Young, Type 3	Maturity-Onset Diabetes Of The Young Type 3 MODY3 Mody, Type Iii Mody Type 3 Mody, Type 3 Maturity-Onset Diabetes Of The Young 3 Mody-3 Diabetes Of The Young, Maturity-Onset, Type 3

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06778	IL6ST Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17230	Il6st Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23683	Il6st Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	IL6ST	RGD	RGD:2903
Macaca mulatta	IL6ST	VGNC	VGNC:73734
Mus musculus	IL6ST	MGD	MGI:96560
Canis familiaris	IL6ST	VGNC	VGNC:41994
Bos taurus	IL6ST	VGNC	VGNC:30168
Felis catus	IL6ST	VGNC	VGNC:67783
Others	IL6ST	NCBI