Chlorasquin
Chlorasquin inhibits thymidylate synthetase with an approximate Ki value of 4.9 μM. Chlorasquin is also a folate antagonist, testing the Methotrexate (HY-14519) effect. Chlorasquin binds tighter to dihydrofolate reductase at alkaline pH than does Methotrexate, which is promising for research of antipsoriatic agents.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 18921-73-8
- Fòrmula: C20H19ClN6O5
- Peso molecular:458.86
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Actividad biológica
Descripciòn
Chemical Information
-
No. CAS 18921-73-8
-
Peso molecular 458.86
-
Fòrmula C20H19ClN6O5
-
SMILES
O=C(C[C@H](NC(C1=CC=C(C=C1)NCC2=C(C3=C(N=C(N=C3C=C2)N)N)Cl)=O)C(O)=O)O
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Chello PL, et al. Elevation of dihydrofolate reductase, thymidylate synthetase, and thymidine kinase in cultured mammalian cells after exposure to folate antagonists. Cancer Res. 1976 Jul;36(7 PT 1):2442-9. [Content Brief]
[2]. Hynes J B, et al. Quinazolines as inhibitors of dihydrofolate reductase. 4. Classical analogs of folic and isofolic acids[J]. Journal of Medicinal Chemistry, 1977, 20(4): 588-591. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Chlorasquin Related Classifications
HY-121256 Related Classifications
Powered by Bioz