PIP5K1A - phosphatidylinositol-4-phosphate 5-kinase type 1 alpha Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8394

About PIP5K1A

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:151,195,419-151,249,531 (from NCBI)

This gene has 17 transcripts (splice variants), 239 orthologues and 6 paralogues. Ubiquitous expression in testis (RPKM 22.2), placenta (RPKM 13.0) and 25 other tissues.

Summary

Enables 1-phosphatidylinositol-4-phosphate 5-kinase activity and kinase binding activity. Involved in several processes, including activation of GTPase activity; focal adhesion assembly; and ruffle assembly. Located in several cellular components, including lamellipodium; nuclear speck; and ruffle membrane. Colocalizes with mRNA cleavage and polyadenylation specificity factor complex. [provided by Alliance of Genome Resources, Apr 2022]

PIP5K1A Products (5)

mRNA Protein Name
NM_001135636.2 NP_001129108.1 phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform 3
NM_001135637.2 NP_001129109.1 phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform 4
NM_001135638.2 NP_001129110.1 phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform 1
NM_001330689.2 NP_001317618.1 phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform 5
NM_003557.3 NP_003548.1 phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Referencias Source
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity IDA
IDA: Inferred from direct assay
15157668 GOA
enables kinase binding IDA
IDA: Inferred from direct assay
15157668 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15157668 GOA
Biological Process GO Annotation Evidence Referencias Source
involved in actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
20660631 GOA
involved in activation of GTPase activity IMP
IMP: Inferred from mutant phenotype
20660631 GOA
involved in cell chemotaxis IMP
IMP: Inferred from mutant phenotype
20660631 GOA
involved in focal adhesion assembly IMP
IMP: Inferred from mutant phenotype
20660631 GOA
involved in phospholipid biosynthetic process IDA
IDA: Inferred from direct assay
15157668 GOA
involved in protein localization to plasma membrane IMP
IMP: Inferred from mutant phenotype
20660631 GOA
involved in ruffle assembly IMP
IMP: Inferred from mutant phenotype
20660631 GOA
Cellular Component GO Annotation Evidence Referencias Source
located in lamellipodium IDA
IDA: Inferred from direct assay
15157668 GOA
part of mRNA cleavage and polyadenylation specificity factor complex IDA
IDA: Inferred from direct assay
18305108 GOA
located in nuclear speck IDA
IDA: Inferred from direct assay
18288197 GOA
located in nucleus IDA
IDA: Inferred from direct assay
15157668 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
20660631 GOA
located in ruffle membrane IDA
IDA: Inferred from direct assay
20660631 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PIP5K1A Protein Structure

PIP5K

PIP5K: Phosphatidylinositol-4-phosphate 5-Kinase (164 - 448)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 562 a.a.
Protein Preferred Names Protein Names

phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

  • 68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha

PIP5K1A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Referencias
Intra
PIP5K1A Q99755 KRAS Homo sapiens P01116
Pull Down
30194290
Intra
PIP5K1A Q99755 KRAS Homo sapiens P01116
Anti Bait CoIP
30194290
Intra
PIP5K1A Q99755 KRAS Homo sapiens P01116
Anti Tag CoIP
30194290
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-E70631 PIP5K1A Recombinant Human Active Lipid Kinase / Unkown
HY-RS10566 PIP5K1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19547 Pip5k1a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26043 Pip5k1a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PIP5K1A VGNC VGNC:55656
Mus musculus PIP5K1A MGD MGI:107929
Macaca mulatta PIP5K1A VGNC VGNC:100037
Felis catus PIP5K1A VGNC VGNC:80303
Rattus norvegicus PIP5K1A RGD RGD:1306127
Others PIP5K1A NCBI